TFRC protein expression summary - The Human Protein Atlas

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TFRC

SUMMARY

TISSUE

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BLOOD

GENERAL INFORMATIONⁱ General description of the gene and encoded protein(s) using information from HGNC and Ensembl, as well as predictions made as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Gene name according to HGNC.	TFRC (CD71, p90, TFR1)
Gene description	Transferrin receptor
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane,Secreted
Number of transcriptsⁱ Number of protein-coding transcribed from this gene as defined by Ensembl.	4
Protein evidenceⁱ Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.	Evidence at protein level
	SHOW MORE

TISSUE ATLASⁱ

RNA tissue specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Tissue enhanced (placenta)
RNA tissue distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Protein expressionⁱ A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation. "Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile. Read more	Cytoplasmic and membranous expression in most tissues, highly abundant in placental trophoblasts and bone marrow cells.

CELL ATLASⁱ

Main locationⁱ The main location is characterized by presence in all tested cell lines and/or increased intensity compared to other locations. It is highlighted in the illustration to the right. If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively.	Localized to the Endosomes, Lysosomes
Summaryⁱ Show complete data for human cells assay. The location(s) are highlighted in the illustration on the right.	Mainly localized to the endosomes & lysosomes.
RNA cell specificityⁱ The cell lines in the Human Protein Atlas have been analyzed by RNA-seq to estimate the transcript abundance of each protein-coding gene. The RNA-seq data was then used to classify all genes according to their cell line-specific expression into one of six different categories, defined based on the total set of all NX values in all analyzed cell lines. Read more	Low cell line specificity
RNA cell distributionⁱ Classification of genes according to distribution of their RNA expression among the cell lines within the HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all

PATHOLOGY ATLASⁱ

Liver cancer p<0.001

Cancer expression specificity (RNA)ⁱ Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. Read more	Low cancer specificity
Cancer expression distribution (RNA)ⁱ Distribution of RNA expression in 17 cancer types is categorized as either detected in single, detected in some, detected in many, detected in all, or not detected. Read more	Detected in all
Prognostic summary	Prognostic marker in liver cancer (unfavourable), thyroid cancer (unfavourable) and cervical cancer (unfavourable)

BRAIN ATLAS

	Human brain	Pig brain	Mouse brain
Regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity	Low region specificity	Low region specificity
Regional distributionⁱ The regional distribution category is based on mRNA expression detected above cut off or not in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression is based on a combination of data from GTEX and FANTOM5. The distribution categories include: detected in all, detected in many, detected in some, detected in single and not detected. The classification rules are the same used for the tissue distribution category. Read more	Detected in all	Detected in all	Detected in all

BLOOD ATLAS

Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes. A gene will only have one location and the categories and their hierarchy is: Intracellular and membrane Secreted to blood Secreted in brain Secreted to digestive system Secreted in female reproductive system Secreted in male reproductive system Secreted to extracellular matrix Secreted in other tissues Secreted - unknown location Read more	Secreted to blood
RNA blood cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
RNA blood cell type distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Blood-based immunoassayⁱ The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search. Read more	Detected
Mass spectrometry:ⁱ Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics data set obtained from the PeptideAtlas.	Detected

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	TFRC (HGNC Symbol)
Synonyms	CD71, p90, TFR1
Description	Transferrin receptor (HGNC Symbol)
Entrez gene summary	This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]
Chromosome	3
Cytoband	q29
Chromosome location (bp)	196027183 - 196082189
Protein evidence	Evidence at protein level (all genes)
Protein classⁱ Protein class(es) of the gene product according to selected gene lists. List of protein classes.	Cancer-related genes CD markers Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins Transporters
Ensembl	ENSG00000072274 (version 92.38)
Entrez gene	7037
UniProt	P02786 (UniProt - Evidence at protein level)
neXtProt	NX_P02786
Antibodypedia	TFRC antibodies

PROTEIN BROWSERⁱ

TFRC-201

TFRC-202

TFRC-203

TFRC-205

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TFRC-201 ENSP00000353224 ENST00000360110	P02786 [Direct mapping] Transferrin receptor protein 1 Transferrin receptor protein 1, serum form Show all	Enzymes Peptidases Metallopeptidases CD markers Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0001618 [virus receptor activity] GO:0003723 [RNA binding] GO:0003725 [double-stranded RNA binding] GO:0004998 [transferrin receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005768 [endosome] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005905 [clathrin-coated pit] GO:0006879 [cellular iron ion homeostasis] GO:0006897 [endocytosis] GO:0006898 [receptor-mediated endocytosis] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016323 [basolateral plasma membrane] GO:0030316 [osteoclast differentiation] GO:0030665 [clathrin-coated vesicle membrane] GO:0030890 [positive regulation of B cell proliferation] GO:0031410 [cytoplasmic vesicle] GO:0031623 [receptor internalization] GO:0033570 [transferrin transmembrane transporter activity] GO:0033572 [transferrin transport] GO:0035690 [cellular response to drug] GO:0042102 [positive regulation of T cell proliferation] GO:0042470 [melanosome] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0045780 [positive regulation of bone resorption] GO:0045830 [positive regulation of isotype switching] GO:0046718 [viral entry into host cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] GO:0097286 [iron ion import] GO:1903561 [extracellular vesicle] GO:1990712 [HFE-transferrin receptor complex] GO:1990830 [cellular response to leukemia inhibitory factor] Show all	760 aa 84.9 kDa	No	1
TFRC-202 ENSP00000376197 ENST00000392396	P02786 [Direct mapping] Transferrin receptor protein 1 Transferrin receptor protein 1, serum form Show all	Enzymes Peptidases Metallopeptidases CD markers Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0001618 [virus receptor activity] GO:0003723 [RNA binding] GO:0003725 [double-stranded RNA binding] GO:0004998 [transferrin receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005905 [clathrin-coated pit] GO:0006879 [cellular iron ion homeostasis] GO:0006897 [endocytosis] GO:0006898 [receptor-mediated endocytosis] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016323 [basolateral plasma membrane] GO:0030665 [clathrin-coated vesicle membrane] GO:0030890 [positive regulation of B cell proliferation] GO:0031410 [cytoplasmic vesicle] GO:0031623 [receptor internalization] GO:0033570 [transferrin transmembrane transporter activity] GO:0033572 [transferrin transport] GO:0035690 [cellular response to drug] GO:0042102 [positive regulation of T cell proliferation] GO:0042470 [melanosome] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0045830 [positive regulation of isotype switching] GO:0046718 [viral entry into host cell] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] GO:0097286 [iron ion import] GO:1903561 [extracellular vesicle] GO:1990712 [HFE-transferrin receptor complex] Show all	760 aa 84.9 kDa	No	1
TFRC-203 ENSP00000390133 ENST00000420415	G3V0E5 [Direct mapping] Transferrin receptor (P90, CD71), isoform CRA_c; Transferrin receptor protein 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0004998 [transferrin receptor activity] GO:0005886 [plasma membrane] GO:0006879 [cellular iron ion homeostasis] GO:0006898 [receptor-mediated endocytosis] GO:0033570 [transferrin transmembrane transporter activity] GO:0033572 [transferrin transport] Show all	679 aa 76 kDa	No	0
TFRC-205 ENSP00000414015 ENST00000426789	H7C3V5 [Direct mapping] Transferrin receptor protein 1 Show all	Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0004998 [transferrin receptor activity] GO:0005886 [plasma membrane] GO:0006879 [cellular iron ion homeostasis] GO:0006898 [receptor-mediated endocytosis] GO:0033572 [transferrin transport] Show all	118 aa 13.7 kDa	No	0

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