SNCB

GENERAL INFORMATION

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Gene name

SNCB

Gene description

Synuclein, beta

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (cerebellum, cerebral cortex, hippocampus)

Protein evidence

Evidence at protein level

Protein localization

Selective expression in neuropil and cells in the CNS.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA035876 , CAB002681
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (cerebral cortex)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (cerebellum, cerebral cortex, hippocampus)

Organ

Expression



GENE INFORMATION

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Gene name

SNCB

Synonyms

Description

Synuclein, beta (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q35.2

Chromosome location (bp)

176620084 - 176630556

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000074317 (version 78.38)

Entrez gene

6620

UniProt

Q16143 (UniProt - Evidence at protein level)

neXtProt

NX_Q16143

Antibodypedia

SNCB antibodies


PROTEIN BROWSER

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ENST00000310112
 
ENST00000393693
 
ENST00000506696
 
ENST00000510387
 
ENST00000614675
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SNCB-001 ENSP00000308057
ENST00000310112
Q16143
Show all »
Show » Show » 134 14.3 No 0
SNCB-002 ENSP00000377296
ENST00000393693
Q16143
Show all »
Show » Show » 134 14.3 No 0
SNCB-003 ENSP00000422223
ENST00000506696
Q16143
Show all »
Show » Show » 134 14.3 No 0
SNCB-005 ENSP00000424073
ENST00000510387
Q16143
Show all »
Show » Show » 134 14.3 No 0
SNCB-201 ENSP00000479489
ENST00000614675
G4Y816
Show all »
Show » 120 12.9 No 0