NEBL

GENERAL INFORMATION

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Gene name

NEBL

Gene description

Nebulette

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (heart muscle)
GTEx:Tissue enhanced (heart muscle)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in several different tissues, most abundant in heart muscle.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA013994 , HPA013995
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (heart muscle)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (heart muscle)

Organ

Expression



GENE INFORMATION

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Gene name

NEBL

Synonyms

Description

Nebulette (HGNC Symbol)

Entrez gene summary

This gene encodes a nebulin like protein that is abundantly expressed in cardiac muscle. The encoded protein binds actin and interacts with thin filaments and Z-line associated proteins in striated muscle. This protein may be involved in cardiac myofibril assembly. A shorter isoform of this protein termed LIM nebulette is expressed in non-muscle cells and may function as a component of focal adhesion complexes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Chromosome

10

Cytoband

p12.31

Chromosome location (bp)

20779973 - 21174187

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000078114 (version 78.38)

Entrez gene

10529

UniProt

O76041 (UniProt - Evidence at protein level)

neXtProt

NX_O76041

Antibodypedia

NEBL antibodies


PROTEIN BROWSER

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ENST00000377119
 
ENST00000377122
 
ENST00000377159
 
ENST00000417816
 
ENST00000434381
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NEBL-003 ENSP00000393896
ENST00000417816
O76041
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Show » Show » 270 31.2 No 0
NEBL-004 ENSP00000366326
ENST00000377122
O76041
Show all »
Show » Show » 1014 116.5 No 0
NEBL-007 ENSP00000366323
ENST00000377119
Q5JUU8
Show all »
Show » 231 26.4 No 0
NEBL-009 ENSP00000396512
ENST00000434381
Q5JUU7
Show all »
Show » 117 13.3 No 0
NEBL-201 ENSP00000366364
ENST00000377159
Show » Show » 1016 116.6 No 0