SRCAP

GENERAL INFORMATION

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Gene name

SRCAP

Gene description

Snf2-related CREBBP activator protein

Protein class

Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most of the normal tissues displayed weak to moderate nuclear positivity most often together with a weaker cytoplasmic staining. The liver, ovary, most cells in CNS and lymphoid cells were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA028929
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SRCAP (HGNC Symbol)

Synonyms

DOMO1, EAF1, KIAA0309, SWR1

Description

Snf2-related CREBBP activator protein (HGNC Symbol)

Entrez gene summary

This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]

Chromosome

16

Cytoband

p11.2

Chromosome location (bp)

30698209 - 30745194

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000080603 (version 78.38)

Entrez gene

10847

UniProt

Q6ZRS2 (UniProt - Evidence at protein level)

neXtProt

NX_Q6ZRS2

Antibodypedia

SRCAP antibodies


PROTEIN BROWSER

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ENST00000262518
 
ENST00000395059
 
ENST00000411466
 
ENST00000483083
 
ENST00000615541
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SRCAP-001 ENSP00000262518
ENST00000262518
Q6ZRS2
Show all »
Show » Show » 3230 343.6 No 0
SRCAP-003 ENSP00000483329
ENST00000483083
Show » Show » 1610 168.9 No 0
SRCAP-004 ENSP00000405186
ENST00000411466
C9J4U4
Show all »
Show » 100 10 No 0
SRCAP-201 ENSP00000378499
ENST00000395059
Show » Show » 2971 315.6 No 0
SRCAP-202 ENSP00000477871
ENST00000615541
Show » Show » 108 11.8 No 1