CPB2

GENERAL INFORMATION

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Gene name

CPB2

Gene description

Carboxypeptidase B2 (plasma)

Protein class

Candidate cardiovascular disease genes
Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein localization

Distinct positivity in plasma.

ANTIBODY RELIABILITY

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Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 1 antibody.
HPA004146
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (liver)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (liver)

Organ

Expression



GENE INFORMATION

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Gene name

CPB2 (HGNC Symbol)

Synonyms

CPU, PCPB, TAFI

Description

Carboxypeptidase B2 (plasma) (HGNC Symbol)

Entrez gene summary

Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Chromosome

13

Cytoband

q14.13

Chromosome location (bp)

46053186 - 46105076

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000080618 (version 78.38)

Entrez gene

1361

UniProt

Q96IY4 (UniProt - Evidence at protein level)

neXtProt

NX_Q96IY4

Antibodypedia

CPB2 antibodies


PROTEIN BROWSER

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ENST00000181383
 
ENST00000439329
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CPB2-001 ENSP00000181383
ENST00000181383
Q96IY4
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Show » Show » 423 48.4 Yes 0
CPB2-201 ENSP00000400714
ENST00000439329
Show » Show » 386 44 Yes 0