STRADB

GENERAL INFORMATION

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Gene name

STRADB

Gene description

STE20-related kinase adaptor beta

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in selected cell types including pancreatic islets, heart, hepaocytes, renal tubules and gallbladder.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA026549 , HPA028520
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

STRADB (HGNC Symbol)

Synonyms

ALS2CR2, CALS-21, ILPIP, ILPIPA, PAPK

Description

STE20-related kinase adaptor beta (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Chromosome

2

Cytoband

q33.1

Chromosome location (bp)

201387858 - 201480846

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000082146 (version 78.38)

Entrez gene

55437

UniProt

Q9C0K7 (UniProt - Evidence at protein level)

neXtProt

NX_Q9C0K7

Antibodypedia

STRADB antibodies


PROTEIN BROWSER

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ENST00000194530
 
ENST00000392249
 
ENST00000415688
 
ENST00000458269
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STRADB-001 ENSP00000194530
ENST00000194530
Q9C0K7
Show all »
Show » Show » 418 47 No 0
STRADB-003 ENSP00000376080
ENST00000392249
Q9C0K7
Show all »
Show » Show » 377 42.4 No 0
STRADB-006 ENSP00000409552
ENST00000458269
C9JSU7
Show all »
Show » Show » 194 22 No 0
STRADB-009 ENSP00000413574
ENST00000415688
Show » Show » 89 10.1 No 0