DLG3

GENERAL INFORMATION

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Gene name

DLG3

Gene description

Discs, large homolog 3 (Drosophila)

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Distinct nuclear and cytoplasmic positivity was seen in cells of the CNS. Remaining normal tissues were in general negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA001733
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

DLG3 (HGNC Symbol)

Synonyms

KIAA1232, MRX90, NE-Dlg, NEDLG, PPP1R82, SAP-102, SAP102

Description

Discs, large homolog 3 (Drosophila) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

Chromosome

X

Cytoband

q13.1

Chromosome location (bp)

70444861 - 70505490

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000082458 (version 78.38)

Entrez gene

1741

UniProt

Q92796 (UniProt - Evidence at protein level)

neXtProt

NX_Q92796

Antibodypedia

DLG3 antibodies


PROTEIN BROWSER

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ENST00000194900
 
ENST00000374355
 
ENST00000374360
 
ENST00000542398
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DLG3-001 ENSP00000363480
ENST00000374360
Q92796
Show all »
Show » Show » 817 90.3 No 0
DLG3-002 ENSP00000363475
ENST00000374355
Q92796
Show all »
Show » Show » 512 57.9 No 0
DLG3-003 ENSP00000194900
ENST00000194900
Q5JUW8
Show all »
Show » Show » 849 93.6 No 0
DLG3-201 ENSP00000441393
ENST00000542398
Q92796
Show all »
Show » Show » 366 42.1 No 0