GNAS protein expression summary - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and encoded protein(s) using information from HGNC and Ensembl, as well as predictions made as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Gene name according to HGNC.	GNAS (GNAS1, GNASXL, GPSA, NESP, NESP55, SCG6, SgVI)
Gene description	GNAS complex locus
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcribed from this gene as defined by Ensembl.	22
Protein evidenceⁱ Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.	Evidence at protein level
	SHOW MORE

TISSUE ATLASⁱ

RNA tissue specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Tissue enhanced (pituitary gland, thyroid gland)
RNA tissue distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Protein expressionⁱ A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation. "Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile. Read more	Membranous and cytoplasmic expression in several different tissue types.

CELL ATLASⁱ

Main locationⁱ The main location is characterized by presence in all tested cell lines and/or increased intensity compared to other locations. It is highlighted in the illustration to the right. If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively.	Localized to the Nucleoplasm
Additional locationⁱ Additional locations are characterized by either a markedly lower staining intensity than the main location, or that it is only observed in a subset of the cell lines. They are highlighted in the illustration to the right. If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively.	In addition localized to the Plasma membrane, Cytosol
Summaryⁱ Show complete data for human cells assay. The location(s) are highlighted in the illustration on the right.	Mainly localized to the nucleoplasm. In addition localized to the plasma membrane & cytosol.
RNA cell specificityⁱ The cell lines in the Human Protein Atlas have been analyzed by RNA-seq to estimate the transcript abundance of each protein-coding gene. The RNA-seq data was then used to classify all genes according to their cell line-specific expression into one of six different categories, defined based on the total set of all NX values in all analyzed cell lines. Read more	Low cell line specificity
RNA cell distributionⁱ Classification of genes according to distribution of their RNA expression among the cell lines within the HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all

PATHOLOGY ATLASⁱ

Renal cancer p<0.001

Cancer expression specificity (RNA)ⁱ Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. Read more	Low cancer specificity
Cancer expression distribution (RNA)ⁱ Distribution of RNA expression in 17 cancer types is categorized as either detected in single, detected in some, detected in many, detected in all, or not detected. Read more	Detected in all
Prognostic summary	Prognostic marker in renal cancer (unfavourable) and ovarian cancer (favourable)

BRAIN ATLAS

	Human brain	Pig brain	Mouse brain
Regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity	Low region specificity	Low region specificity
Regional distributionⁱ The regional distribution category is based on mRNA expression detected above cut off or not in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression is based on a combination of data from GTEX and FANTOM5. The distribution categories include: detected in all, detected in many, detected in some, detected in single and not detected. The classification rules are the same used for the tissue distribution category. Read more	Detected in all	Detected in all	Detected in all

BLOOD ATLAS

Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes. A gene will only have one location and the categories and their hierarchy is: Intracellular and membrane Secreted to blood Secreted in brain Secreted to digestive system Secreted in female reproductive system Secreted in male reproductive system Secreted to extracellular matrix Secreted in other tissues Secreted - unknown location Read more	Intracellular and membrane
RNA blood cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
RNA blood cell type distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Blood-based immunoassayⁱ The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search. Read more	Not analysed since only proteins predicted to be actively secreted to blood is analysed here
Mass spectrometry:ⁱ Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics data set obtained from the PeptideAtlas.	Not detected

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	GNAS (HGNC Symbol)
Synonyms	GNAS1, GNASXL, GPSA, NESP, NESP55, SCG6, SgVI
Description	GNAS complex locus (HGNC Symbol)
Entrez gene summary	This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]
Chromosome	20
Cytoband	q13.32
Chromosome location (bp)	58839718 - 58911192
Protein evidence	Evidence at protein level (all genes)
Protein classⁱ Protein class(es) of the gene product according to selected gene lists. List of protein classes.	Cancer-related genes Disease related genes Potential drug targets Predicted intracellular proteins Transporters
Ensembl	ENSG00000087460 (version 92.38)
Entrez gene	2778
UniProt	O95467 (UniProt - Evidence at transcript level), P63092 (UniProt - Evidence at protein level), P84996 (UniProt - Evidence at protein level), Q5JWF2 (UniProt - Evidence at protein level)
neXtProt	NX_O95467, NX_P63092, NX_P84996, NX_Q5JWF2
Antibodypedia	GNAS antibodies

PROTEIN BROWSERⁱ

GNAS-201

GNAS-202

GNAS-203

GNAS-204

GNAS-205

GNAS-206

GNAS-207

GNAS-208

GNAS-209

GNAS-210

GNAS-211

GNAS-212

GNAS-213

GNAS-214

GNAS-215

GNAS-216

GNAS-217

GNAS-218

GNAS-219

GNAS-256

GNAS-257

GNAS-258

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GNAS-201 ENSP00000265620 ENST00000265620	P63092 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Show all	Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0000166 [nucleotide binding] GO:0003091 [renal water homeostasis] GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005834 [heterotrimeric G-protein complex] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway] GO:0007608 [sensory perception of smell] GO:0016020 [membrane] GO:0019001 [guanyl nucleotide binding] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0031224 [intrinsic component of membrane] GO:0031683 [G-protein beta/gamma-subunit complex binding] GO:0032588 [trans-Golgi network membrane] GO:0043547 [positive regulation of GTPase activity] GO:0043950 [positive regulation of cAMP-mediated signaling] GO:0046872 [metal ion binding] GO:0046907 [intracellular transport] GO:0048589 [developmental growth] GO:0050796 [regulation of insulin secretion] GO:0050890 [cognition] GO:0060348 [bone development] GO:0060789 [hair follicle placode formation] GO:0070062 [extracellular exosome] GO:0070527 [platelet aggregation] GO:0071377 [cellular response to glucagon stimulus] GO:0071380 [cellular response to prostaglandin E stimulus] GO:0071870 [cellular response to catecholamine stimulus] GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway] Show all	379 aa 44.2 kDa	No	0
GNAS-202 ENSP00000304472 ENST00000306090	A0A0A0MR13 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Show all	GO:0000166 [nucleotide binding] GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005525 [GTP binding] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0019001 [guanyl nucleotide binding] GO:0031683 [G-protein beta/gamma-subunit complex binding] Show all	158 aa 18.7 kDa	No	0
GNAS-203 ENSP00000302237 ENST00000306120	P84996 [Direct mapping] Protein ALEX Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0001726 [ruffle] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0009966 [regulation of signal transduction] GO:0016020 [membrane] GO:0042995 [cell projection] GO:0048589 [developmental growth] GO:0050890 [cognition] GO:0060348 [bone development] GO:0060789 [hair follicle placode formation] GO:0070527 [platelet aggregation] Show all	625 aa 67.8 kDa	No	0
GNAS-204 ENSP00000323571 ENST00000313949	O95467 [Direct mapping] Neuroendocrine secretory protein 55 LHAL tetrapeptide GPIPIRRH peptide Show all	THUMBUP predicted membrane proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0003674 [molecular_function] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007565 [female pregnancy] GO:0009306 [protein secretion] GO:0030133 [transport vesicle] GO:0031410 [cytoplasmic vesicle] GO:0040015 [negative regulation of multicellular organism growth] GO:0048471 [perinuclear region of cytoplasm] GO:0071107 [response to parathyroid hormone] Show all	245 aa 28 kDa	Yes	0
GNAS-205 ENSP00000345971 ENST00000338783	A2A2R6 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Show all	GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0019001 [guanyl nucleotide binding] GO:0031683 [G-protein beta/gamma-subunit complex binding] Show all	61 aa 7 kDa	No	0
GNAS-206 ENSP00000265621 ENST00000349036	Q5JWE9 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Show all	GO:0000166 [nucleotide binding] GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005525 [GTP binding] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0019001 [guanyl nucleotide binding] GO:0031683 [G-protein beta/gamma-subunit complex binding] Show all	193 aa 21.9 kDa	No	0
GNAS-207 ENSP00000346328 ENST00000354359	P63092 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Show all	Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0000166 [nucleotide binding] GO:0003091 [renal water homeostasis] GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005834 [heterotrimeric G-protein complex] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway] GO:0007608 [sensory perception of smell] GO:0016020 [membrane] GO:0019001 [guanyl nucleotide binding] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0031224 [intrinsic component of membrane] GO:0031683 [G-protein beta/gamma-subunit complex binding] GO:0032588 [trans-Golgi network membrane] GO:0043547 [positive regulation of GTPase activity] GO:0043950 [positive regulation of cAMP-mediated signaling] GO:0046872 [metal ion binding] GO:0046907 [intracellular transport] GO:0048589 [developmental growth] GO:0050796 [regulation of insulin secretion] GO:0050890 [cognition] GO:0060348 [bone development] GO:0060789 [hair follicle placode formation] GO:0070062 [extracellular exosome] GO:0070527 [platelet aggregation] GO:0071377 [cellular response to glucagon stimulus] GO:0071380 [cellular response to prostaglandin E stimulus] GO:0071870 [cellular response to catecholamine stimulus] GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway] Show all	395 aa 45.8 kDa	No	0
GNAS-208 ENSP00000360115 ENST00000371075	O95467 [Direct mapping] Neuroendocrine secretory protein 55 LHAL tetrapeptide GPIPIRRH peptide Show all	THUMBUP predicted membrane proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0003674 [molecular_function] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007565 [female pregnancy] GO:0009306 [protein secretion] GO:0030133 [transport vesicle] GO:0031410 [cytoplasmic vesicle] GO:0040015 [negative regulation of multicellular organism growth] GO:0048471 [perinuclear region of cytoplasm] GO:0071107 [response to parathyroid hormone] Show all	245 aa 28 kDa	Yes	0
GNAS-209 ENSP00000360122 ENST00000371081	Q5JWD1 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Show all	GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0019001 [guanyl nucleotide binding] GO:0031683 [G-protein beta/gamma-subunit complex binding] Show all	87 aa 9.6 kDa	No	0
GNAS-210 ENSP00000360126 ENST00000371085	P63092 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short A0A0S2Z3H8 [Target identity:100%; Query identity:100%] GNAS complex locus isoform 1 Show all	Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0000166 [nucleotide binding] GO:0003091 [renal water homeostasis] GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005834 [heterotrimeric G-protein complex] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway] GO:0007608 [sensory perception of smell] GO:0016020 [membrane] GO:0019001 [guanyl nucleotide binding] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0031224 [intrinsic component of membrane] GO:0031683 [G-protein beta/gamma-subunit complex binding] GO:0032588 [trans-Golgi network membrane] GO:0043547 [positive regulation of GTPase activity] GO:0043950 [positive regulation of cAMP-mediated signaling] GO:0046872 [metal ion binding] GO:0046907 [intracellular transport] GO:0048589 [developmental growth] GO:0050796 [regulation of insulin secretion] GO:0050890 [cognition] GO:0060348 [bone development] GO:0060789 [hair follicle placode formation] GO:0070062 [extracellular exosome] GO:0070527 [platelet aggregation] GO:0071377 [cellular response to glucagon stimulus] GO:0071380 [cellular response to prostaglandin E stimulus] GO:0071870 [cellular response to catecholamine stimulus] GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway] Show all	394 aa 45.7 kDa	No	0
GNAS-211 ENSP00000360136 ENST00000371095	P63092 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short A0A0S2Z3S5 [Target identity:100%; Query identity:100%] GNAS complex locus isoform 2 Show all	Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Potential drug targets Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0000166 [nucleotide binding] GO:0003091 [renal water homeostasis] GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005834 [heterotrimeric G-protein complex] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway] GO:0007608 [sensory perception of smell] GO:0016020 [membrane] GO:0019001 [guanyl nucleotide binding] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0031224 [intrinsic component of membrane] GO:0031683 [G-protein beta/gamma-subunit complex binding] GO:0032588 [trans-Golgi network membrane] GO:0043547 [positive regulation of GTPase activity] GO:0043950 [positive regulation of cAMP-mediated signaling] GO:0046872 [metal ion binding] GO:0046907 [intracellular transport] GO:0048589 [developmental growth] GO:0050796 [regulation of insulin secretion] GO:0050890 [cognition] GO:0060348 [bone development] GO:0060789 [hair follicle placode formation] GO:0070062 [extracellular exosome] GO:0070527 [platelet aggregation] GO:0071377 [cellular response to glucagon stimulus] GO:0071380 [cellular response to prostaglandin E stimulus] GO:0071870 [cellular response to catecholamine stimulus] GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway] Show all	380 aa 44.3 kDa	No	0
GNAS-212 ENSP00000360139 ENST00000371098	O95467 [Direct mapping] Neuroendocrine secretory protein 55 LHAL tetrapeptide GPIPIRRH peptide Show all	THUMBUP predicted membrane proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0003674 [molecular_function] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007565 [female pregnancy] GO:0009306 [protein secretion] GO:0030133 [transport vesicle] GO:0031410 [cytoplasmic vesicle] GO:0040015 [negative regulation of multicellular organism growth] GO:0048471 [perinuclear region of cytoplasm] GO:0071107 [response to parathyroid hormone] Show all	245 aa 28 kDa	Yes	0
GNAS-213 ENSP00000360140 ENST00000371099	X6R7U9 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Show all		720 aa 74.3 kDa	No	0
GNAS-214 ENSP00000360141 ENST00000371100	Q5JWF2 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0000166 [nucleotide binding] GO:0001501 [skeletal system development] GO:0001894 [tissue homeostasis] GO:0001958 [endochondral ossification] GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005159 [insulin-like growth factor receptor binding] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005829 [cytosol] GO:0005834 [heterotrimeric G-protein complex] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0006306 [DNA methylation] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway] GO:0007606 [sensory perception of chemical stimulus] GO:0009791 [post-embryonic development] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0019001 [guanyl nucleotide binding] GO:0030425 [dendrite] GO:0031683 [G-protein beta/gamma-subunit complex binding] GO:0031698 [beta-2 adrenergic receptor binding] GO:0031748 [D1 dopamine receptor binding] GO:0031852 [mu-type opioid receptor binding] GO:0035116 [embryonic hindlimb morphogenesis] GO:0035255 [ionotropic glutamate receptor binding] GO:0035264 [multicellular organism growth] GO:0040032 [post-embryonic body morphogenesis] GO:0042493 [response to drug] GO:0043588 [skin development] GO:0045669 [positive regulation of osteoblast differentiation] GO:0045672 [positive regulation of osteoclast differentiation] GO:0046872 [metal ion binding] GO:0048589 [developmental growth] GO:0048701 [embryonic cranial skeleton morphogenesis] GO:0050890 [cognition] GO:0051216 [cartilage development] GO:0051430 [corticotropin-releasing hormone receptor 1 binding] GO:0060348 [bone development] GO:0060789 [hair follicle placode formation] GO:0070062 [extracellular exosome] GO:0070527 [platelet aggregation] GO:0071514 [genetic imprinting] GO:2000828 [regulation of parathyroid hormone secretion] Show all	1037 aa 111 kDa	No	0
GNAS-215 ENSP00000360143 ENST00000371102	Q5JWF2 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0000166 [nucleotide binding] GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005159 [insulin-like growth factor receptor binding] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005829 [cytosol] GO:0005834 [heterotrimeric G-protein complex] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway] GO:0007191 [adenylate cyclase-activating dopamine receptor signaling pathway] GO:0007606 [sensory perception of chemical stimulus] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0019001 [guanyl nucleotide binding] GO:0031683 [G-protein beta/gamma-subunit complex binding] GO:0031698 [beta-2 adrenergic receptor binding] GO:0031748 [D1 dopamine receptor binding] GO:0031852 [mu-type opioid receptor binding] GO:0035255 [ionotropic glutamate receptor binding] GO:0046872 [metal ion binding] GO:0048589 [developmental growth] GO:0050890 [cognition] GO:0051430 [corticotropin-releasing hormone receptor 1 binding] GO:0060348 [bone development] GO:0060789 [hair follicle placode formation] GO:0070062 [extracellular exosome] GO:0070527 [platelet aggregation] Show all	1023 aa 109.6 kDa	No	0
GNAS-216 ENSP00000416234 ENST00000419558	H0Y7Z6 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Show all	GO:0071107 [response to parathyroid hormone] Show all	113 aa 12.7 kDa	No	0
GNAS-217 ENSP00000412356 ENST00000423897	H0Y7E8 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Show all	GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0019001 [guanyl nucleotide binding] GO:0031683 [G-protein beta/gamma-subunit complex binding] Show all	93 aa 10.4 kDa	No	0
GNAS-218 ENSP00000412424 ENST00000450130	H0Y7F4 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Show all	GO:0000166 [nucleotide binding] GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005525 [GTP binding] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0019001 [guanyl nucleotide binding] GO:0031683 [G-protein beta/gamma-subunit complex binding] Show all	199 aa 22.7 kDa	No	0
GNAS-219 ENSP00000392000 ENST00000453292	A2A2S1 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Show all	GO:0071107 [response to parathyroid hormone] Show all	166 aa 19 kDa	No	0
GNAS-256 ENSP00000474802 ENST00000603546	S4R3V9 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Show all	GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005525 [GTP binding] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0019001 [guanyl nucleotide binding] GO:0031683 [G-protein beta/gamma-subunit complex binding] Show all	120 aa 13.6 kDa	No	0
GNAS-257 ENSP00000474219 ENST00000604005	S4R3E3 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Show all	GO:0000166 [nucleotide binding] GO:0003924 [GTPase activity] GO:0004871 [signal transducer activity] GO:0005525 [GTP binding] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0019001 [guanyl nucleotide binding] GO:0031683 [G-protein beta/gamma-subunit complex binding] Show all	160 aa 18.3 kDa	No	0
GNAS-258 ENSP00000491441 ENST00000639562	A0A1W2PPB2 [Direct mapping] Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Show all		184 aa 21 kDa	No	0