ANGPT2

GENERAL INFORMATION

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Gene name

ANGPT2

Gene description

Angiopoietin 2

Protein class

Cancer-related genes
Plasma proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

Secreted

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in several tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Data reliability

Uncertain based on 2 antibodies.
CAB011437 , CAB017626
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

ANGPT2 (HGNC Symbol)

Synonyms

Ang2

Description

Angiopoietin 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

p23.1

Chromosome location (bp)

6499651 - 6563409

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000091879 (version 78.38)

Entrez gene

285

UniProt

O15123 (UniProt - Evidence at protein level)

neXtProt

NX_O15123

Antibodypedia

ANGPT2 antibodies


PROTEIN BROWSER

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ENST00000325203
 
ENST00000338312
 
ENST00000523120
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ANGPT2-001 ENSP00000314897
ENST00000325203
O15123
Show all »
Show » Show » 496 56.9 Yes 0
ANGPT2-002 ENSP00000343517
ENST00000338312
O15123
Show all »
Show » Show » 444 51 Yes 0
ANGPT2-003 ENSP00000428023
ENST00000523120
E7EVQ3
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Show » Show » 459 52.6 Yes 0