SH2D3C

GENERAL INFORMATION

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Gene name

SH2D3C

Gene description

SH2 domain containing 3C

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Trophoblastic cells, subset of cells in bone marrow, red pulp of spleen and non germinal center cells of lymphoid tissues exhibited strong cytoplasmic immunoreactivity. Most remaining normal tissues were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA047586
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

SH2D3C (HGNC Symbol)

Synonyms

NSP3

Description

SH2 domain containing 3C (HGNC Symbol)

Entrez gene summary

This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Chromosome

9

Cytoband

q34.11

Chromosome location (bp)

127738317 - 127778741

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000095370 (version 78.38)

Entrez gene

10044

UniProt

Q8N5H7 (UniProt - Evidence at protein level)

neXtProt

NX_Q8N5H7

Antibodypedia

SH2D3C antibodies


PROTEIN BROWSER

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ENST00000314830
 
ENST00000373276
 
ENST00000373277
 
ENST00000414380
 
ENST00000420366
 
ENST00000429553
 
ENST00000440630
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SH2D3C-002 ENSP00000401641
ENST00000440630
Show » 325 35.2 No 0
SH2D3C-004 ENSP00000317817
ENST00000314830
Q8N5H7
Show all »
Show » Show » 860 94.4 No 0
SH2D3C-007 ENSP00000362374
ENST00000373277
Q8N5H7
Show all »
Show » Show » 703 77.1 No 0
SH2D3C-008 ENSP00000388536
ENST00000420366
Q8N5H7
Show all »
Show » Show » 702 77.3 No 0
SH2D3C-010 ENSP00000413760
ENST00000414380
Q5JU32
Show all »
Show » 196 22.1 No 0
SH2D3C-201 ENSP00000362373
ENST00000373276
Q8N5H7
Show all »
Show » Show » 792 86.4 No 0
SH2D3C-202 ENSP00000394632
ENST00000429553
Q8N5H7
Show all »
Show » Show » 506 55.2 No 0