HIRA

GENERAL INFORMATION

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Gene name

HIRA

Gene description

Histone cell cycle regulator

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA050714 , CAB039243 , CAB039244
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

HIRA (HGNC Symbol)

Synonyms

DGCR1, TUP1, TUPLE1

Description

Histone cell cycle regulator (HGNC Symbol)

Entrez gene summary

This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]

Chromosome

22

Cytoband

q11.21

Chromosome location (bp)

19330698 - 19447450

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100084 (version 78.38)

Entrez gene

7290

UniProt

P54198 (UniProt - Evidence at protein level)

neXtProt

NX_P54198

Antibodypedia

HIRA antibodies


PROTEIN BROWSER

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ENST00000263208
 
ENST00000340170
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HIRA-001 ENSP00000263208
ENST00000263208
P54198
Show all »
Show » Show » 1017 111.8 No 0
HIRA-002 ENSP00000345350
ENST00000340170
P54198
Show all »
Show » Show » 810 89.3 No 0