ARSA

GENERAL INFORMATION

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Gene name

ARSA

Gene description

Arylsulfatase A

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous granular cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 2 antibodies.
HPA005554 , CAB025183
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ARSA

Synonyms

Description

Arylsulfatase A (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2010]

Chromosome

22

Cytoband

q13.33

Chromosome location (bp)

50622754 - 50628173

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100299 (version 78.38)

Entrez gene

410

UniProt

P15289 (UniProt - Evidence at protein level)

neXtProt

NX_P15289

Antibodypedia

ARSA antibodies


PROTEIN BROWSER

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ENST00000216124
 
ENST00000356098
 
ENST00000395619
 
ENST00000395621
 
ENST00000453344
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ARSA-001 ENSP00000216124
ENST00000216124
P15289
Show all »
Show » Show » 509 53.8 Yes 0
ARSA-002 ENSP00000412542
ENST00000453344
P15289
Show all »
Show » Show » 423 44.9 No 0
ARSA-003 ENSP00000378981
ENST00000395619
P15289
Show all »
Show » Show » 509 53.8 Yes 0
ARSA-004 ENSP00000348406
ENST00000356098
P15289
Show all »
Show » Show » 509 53.8 Yes 0
ARSA-005 ENSP00000378983
ENST00000395621
P15289
Show all »
Show » Show » 509 53.8 Yes 0