BDKRB1

GENERAL INFORMATION

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Gene name

BDKRB1

Gene description

Bradykinin receptor B1

Protein class

G-protein coupled receptors
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (gallbladder, urinary bladder)
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Moderate to strong cytoplasmic positivity was observed in most normal tissues. Lymphoid tissues and myocytes were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA002935
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (gallbladder, urinary bladder)

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

BDKRB1 (HGNC Symbol)

Synonyms

B1BKR, BKR1, bradyb1

Description

Bradykinin receptor B1 (HGNC Symbol)

Entrez gene summary

Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Chromosome

14

Cytoband

q32.2

Chromosome location (bp)

96255824 - 96268967

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100739 (version 78.38)

Entrez gene

623

UniProt

P46663 (UniProt - Evidence at protein level)

neXtProt

NX_P46663

Antibodypedia

BDKRB1 antibodies


PROTEIN BROWSER

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ENST00000216629
 
ENST00000553356
 
ENST00000611804
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BDKRB1-001 ENSP00000216629
ENST00000216629
P46663
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Show » Show » 353 40.5 No 7
BDKRB1-002 ENSP00000452064
ENST00000553356
G3V4Y2
Show all »
Show » Show » 284 32.4 No 6
BDKRB1-201 ENSP00000479276
ENST00000611804
P46663
Show all »
Show » Show » 353 40.5 No 7