APEX1

GENERAL INFORMATION

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Gene name

APEX1

Gene description

APEX nuclease (multifunctional DNA repair enzyme) 1

Protein class

Cancer-related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

13
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA002564 , CAB004294 , CAB047307
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

APEX1 (HGNC Symbol)

Synonyms

APE, APE-1, APEN, APEX, APX, HAP1, REF-1, REF1

Description

APEX nuclease (multifunctional DNA repair enzyme) 1 (HGNC Symbol)

Entrez gene summary

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q11.2

Chromosome location (bp)

20455191 - 20457772

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100823 (version 78.38)

Entrez gene

328

UniProt

P27695 (UniProt - Evidence at protein level)

neXtProt

NX_P27695

Antibodypedia

APEX1 antibodies


PROTEIN BROWSER

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ENST00000216714
 
ENST00000398030
 
ENST00000438886
 
ENST00000553368
 
ENST00000553681
 
ENST00000555414
 
ENST00000555839
 
ENST00000556054
 
ENST00000557054
 
ENST00000557150
 
ENST00000557181
 
ENST00000557344
 
ENST00000557592
 
 » 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APEX1-001 ENSP00000216714
ENST00000216714
P27695
Show all »
Show » Show » 318 35.6 No 0
APEX1-002 ENSP00000451979
ENST00000555414
P27695
Show all »
Show » Show » 318 35.6 No 0
APEX1-003 ENSP00000416414
ENST00000438886
Show » Show » 150 16.7 No 0
APEX1-006 ENSP00000452212
ENST00000557054
Show » 14 1.5 No 0
APEX1-008 ENSP00000381111
ENST00000398030
P27695
Show all »
Show » Show » 318 35.6 No 0
APEX1-009 ENSP00000451327
ENST00000553681
G3V3M6
Show all »
Show » Show » 263 29.2 No 0
APEX1-013 ENSP00000452137
ENST00000557344
P27695
Show all »
Show » Show » 146 15.9 No 0
APEX1-014 ENSP00000452304
ENST00000557181
G3V5D9
Show all »
Show » Show » 108 11.8 No 0
APEX1-016 ENSP00000452460
ENST00000555839
G3V5Q1
Show all »
Show » Show » 242 27.1 No 0
APEX1-017 ENSP00000451170
ENST00000556054
G3V3C7
Show all »
Show » Show » 174 19.1 No 0
APEX1-018 ENSP00000451060
ENST00000557592
G3V359
Show all »
Show » Show » 172 19.2 No 0
APEX1-019 ENSP00000451491
ENST00000553368
G3V3Y6
Show all »
Show » 42 4.5 No 0
APEX1-021 ENSP00000452418
ENST00000557150
G3V5M0
Show all »
Show » Show » 162 17.8 No 0