CD40LG

GENERAL INFORMATION

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Gene name

CD40LG

Gene description

CD40 ligand

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
CD markers
Disease related genes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (lymph node, tonsil)
GTEx:Tissue enhanced (small intestine, spleen)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in subsets of lymphoid cells in several tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Data reliability

Supportive based on 1 antibody.
HPA045827
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (lymph node, tonsil)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (small intestine, spleen)

Organ

Expression



GENE INFORMATION

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Gene name

CD40LG (HGNC Symbol)

Synonyms

CD154, CD40L, gp39, hCD40L, HIGM1, IMD3, TNFSF5, TRAP

Description

CD40 ligand (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

q26.3

Chromosome location (bp)

136648193 - 136660390

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000102245 (version 78.38)

Entrez gene

959

UniProt

P29965 (UniProt - Evidence at protein level)

neXtProt

NX_P29965

Antibodypedia

CD40LG antibodies


PROTEIN BROWSER

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ENST00000370628
 
ENST00000370629
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD40LG-001 ENSP00000359663
ENST00000370629
P29965
Show all »
Show » Show » 261 29.3 No 1
CD40LG-002 ENSP00000359662
ENST00000370628
Q3L8U2
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Show » Show » 240 27.2 No 1