RIPK2

GENERAL INFORMATION

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Gene name

RIPK2

Gene description

Receptor-interacting serine-threonine kinase 2

Protein class

Cytoskeleton related proteins
Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression mainly in trophoblastic cells in placenta and several different glandular cells.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA015273 , HPA016499
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

RIPK2 (HGNC Symbol)

Synonyms

CARD3, CARDIAK, RICK, RIP2

Description

Receptor-interacting serine-threonine kinase 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

q21.3

Chromosome location (bp)

89757747 - 89791063

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000104312 (version 78.38)

Entrez gene

8767

UniProt

O43353 (UniProt - Evidence at protein level)

neXtProt

NX_O43353

Antibodypedia

RIPK2 antibodies


PROTEIN BROWSER

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ENST00000220751
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RIPK2-001 ENSP00000220751
ENST00000220751
O43353
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