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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Cancer-related genes Disease related genes Enzymes FDA approved drug targets Human disease related genes Plasma proteins RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
q31.2
Chromosome location (bp)
116672196 - 116798377
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).
In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl
The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.
At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.
Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).
The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
MET-201
MET-202
MET-203
MET-204
MET-205
MET-206
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of soft tissues and bone Cancers of the urinary system Nervous system diseases Ear disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165 [MAPK cascade] GO:0000166 [nucleotide binding] GO:0001886 [endothelial cell morphogenesis] GO:0001889 [liver development] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005008 [hepatocyte growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0006909 [phagocytosis] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007275 [multicellular organism development] GO:0007399 [nervous system development] GO:0009925 [basal plasma membrane] GO:0009986 [cell surface] GO:0010507 [negative regulation of autophagy] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016477 [cell migration] GO:0016740 [transferase activity] GO:0017154 [semaphorin receptor activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019903 [protein phosphatase binding] GO:0030182 [neuron differentiation] GO:0031016 [pancreas development] GO:0031116 [positive regulation of microtubule polymerization] GO:0033674 [positive regulation of kinase activity] GO:0035024 [negative regulation of Rho protein signal transduction] GO:0035635 [entry of bacterium into host cell] GO:0042802 [identical protein binding] GO:0043235 [receptor complex] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0048012 [hepatocyte growth factor receptor signaling pathway] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0050918 [positive chemotaxis] GO:0051497 [negative regulation of stress fiber assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0061436 [establishment of skin barrier] GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway] GO:0071526 [semaphorin-plexin signaling pathway] GO:1901299 [negative regulation of hydrogen peroxide-mediated programmed cell death] GO:1905098 [negative regulation of guanyl-nucleotide exchange factor activity] GO:2001028 [positive regulation of endothelial cell chemotaxis]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of soft tissues and bone Cancers of the urinary system Nervous system diseases Ear disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0000166 [nucleotide binding] GO:0001886 [endothelial cell morphogenesis] GO:0001889 [liver development] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005008 [hepatocyte growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0006909 [phagocytosis] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007275 [multicellular organism development] GO:0007399 [nervous system development] GO:0009925 [basal plasma membrane] GO:0009986 [cell surface] GO:0010507 [negative regulation of autophagy] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016477 [cell migration] GO:0016740 [transferase activity] GO:0017154 [semaphorin receptor activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019903 [protein phosphatase binding] GO:0030182 [neuron differentiation] GO:0031016 [pancreas development] GO:0031116 [positive regulation of microtubule polymerization] GO:0033674 [positive regulation of kinase activity] GO:0035024 [negative regulation of Rho protein signal transduction] GO:0035635 [entry of bacterium into host cell] GO:0042802 [identical protein binding] GO:0043235 [receptor complex] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0048012 [hepatocyte growth factor receptor signaling pathway] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0050918 [positive chemotaxis] GO:0051497 [negative regulation of stress fiber assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0061436 [establishment of skin barrier] GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway] GO:0071526 [semaphorin-plexin signaling pathway] GO:1901299 [negative regulation of hydrogen peroxide-mediated programmed cell death] GO:1905098 [negative regulation of guanyl-nucleotide exchange factor activity] GO:2001028 [positive regulation of endothelial cell chemotaxis]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of soft tissues and bone Cancers of the urinary system Nervous system diseases Ear disease Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of soft tissues and bone Cancers of the urinary system Nervous system diseases Ear disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0000166 [nucleotide binding] GO:0001886 [endothelial cell morphogenesis] GO:0001889 [liver development] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0005008 [hepatocyte growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006468 [protein phosphorylation] GO:0006909 [phagocytosis] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007275 [multicellular organism development] GO:0007399 [nervous system development] GO:0009925 [basal plasma membrane] GO:0009986 [cell surface] GO:0010507 [negative regulation of autophagy] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016477 [cell migration] GO:0016740 [transferase activity] GO:0017154 [semaphorin receptor activity] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019903 [protein phosphatase binding] GO:0030182 [neuron differentiation] GO:0031016 [pancreas development] GO:0031116 [positive regulation of microtubule polymerization] GO:0033674 [positive regulation of kinase activity] GO:0035024 [negative regulation of Rho protein signal transduction] GO:0035635 [entry of bacterium into host cell] GO:0042802 [identical protein binding] GO:0043235 [receptor complex] GO:0045944 [positive regulation of transcription by RNA polymerase II] GO:0048012 [hepatocyte growth factor receptor signaling pathway] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0050918 [positive chemotaxis] GO:0051497 [negative regulation of stress fiber assembly] GO:0051897 [positive regulation of protein kinase B signaling] GO:0061436 [establishment of skin barrier] GO:0070495 [negative regulation of thrombin-activated receptor signaling pathway] GO:0071526 [semaphorin-plexin signaling pathway] GO:1901299 [negative regulation of hydrogen peroxide-mediated programmed cell death] GO:1905098 [negative regulation of guanyl-nucleotide exchange factor activity] GO:2001028 [positive regulation of endothelial cell chemotaxis]
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of soft tissues and bone Cancers of the urinary system Nervous system diseases Ear disease Protein evidence (Ezkurdia et al 2014)
MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Cancers of soft tissues and bone Cancers of the urinary system Nervous system diseases Ear disease Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
