PAX4

GENERAL INFORMATION

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Gene name

PAX4

Gene description

Paired box 4

Protein class

Disease related genes
Predicted intracellular proteins
Predicted secreted proteins
Transcription factors

Predicted localization

Intracellular,Secreted

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (duodenum, rectum)
GTEx:Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in many cell types.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA006806 , HPA007182
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (duodenum, rectum)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (testis)

Organ

Expression



GENE INFORMATION

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Gene name

PAX4 (HGNC Symbol)

Synonyms

MODY9

Description

Paired box 4 (HGNC Symbol)

Entrez gene summary

This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

q32.1

Chromosome location (bp)

127610292 - 127615928

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000106331 (version 78.38)

Entrez gene

5078

UniProt

O43316 (UniProt - Evidence at protein level)

neXtProt

NX_O43316

Antibodypedia

PAX4 antibodies


PROTEIN BROWSER

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ENST00000338516
 
ENST00000341640
 
ENST00000378740
 
ENST00000463946
 
ENST00000611453
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PAX4-001 ENSP00000339906
ENST00000341640
O43316
Show all »
Show » Show » 343 37.1 No 0
PAX4-002 ENSP00000451923
ENST00000463946
G3V4Q1
Show all »
Show » Show » 341 36.7 Yes 0
PAX4-004 ENSP00000368014
ENST00000378740
J3KPG0
Show all »
Show » Show » 340 36.7 No 0
PAX4-201 ENSP00000344297
ENST00000338516
J3KPG0
Show all »
Show » Show » 349 37.6 No 0
PAX4-202 ENSP00000477877
ENST00000611453
Q3KNR5
Show all »
Show » Show » 257 28.1 Yes 0