FRK

GENERAL INFORMATION

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Gene name

FRK

Gene description

Fyn-related Src family tyrosine kinase

Protein class

Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Moderate often granular cytoplasmic positivity was observed in most normal tissues. Gastric parietal cells, rectum, appendix, parathyroid and endometrial glands were strongly stained. Placenta, testis and renal glomeruli were mainly negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB025217
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Rectum

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

FRK (HGNC Symbol)

Synonyms

GTK, PTK5, RAK

Description

Fyn-related Src family tyrosine kinase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

q22.1

Chromosome location (bp)

115931149 - 116060758

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000111816 (version 78.38)

Entrez gene

2444

UniProt

P42685 (UniProt - Evidence at protein level)

neXtProt

NX_P42685

Antibodypedia

FRK antibodies


PROTEIN BROWSER

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ENST00000606080
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FRK-001 ENSP00000476145
ENST00000606080
P42685
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