The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Most of the normal tissues displayed weak to moderate nuclear and/or cytoplasmic positivity. Neuronal cells in cerebral cortex displayed strong nuclear and cytoplasmic positivity. Squamous epithelia, liver, female genital tract, breast and smooth muscle cells were generally negative.
Squamous epithelia showed moderate to strong nuclear and cytoplasmic positivity. Respiratory epithelia and Purkinje cells displayed moderate cytoplasmic staining. Moderat positivity was observed in gall bladder and cytotrophoblasts. Remaining normal tissues were in general negative.
Most of the normal tissues displayed weak to moderate cytoplasmic and/or nuclear positivity. Strong cytoplasmic staining was observed in Purkinje cells and ovarian follicles while endothelial cells, Leydig cells and renal glomeruli showed strong nuclear staining. The intestine, liver, pancreas, female genital tract and placental trophoblasts were negative.
Most of the normal cells showed moderate cytoplasmic positivity with additional nuclear staining in some cases. Adrenal cortex, squamous epithelia and neuronal cells were strongly stained. Heart muscle and bile duct cells were negative.