TTK

GENERAL INFORMATION

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Gene name

TTK

Gene description

TTK protein kinase

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (testis)
GTEx:Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous cytoplasmic expression at variable levels.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 3 antibodies.
HPA016834 , CAB010166 , CAB013229
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression



GENE INFORMATION

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Gene name

TTK (HGNC Symbol)

Synonyms

CT96, MPH1, MPS1, MPS1L1

Description

TTK protein kinase (HGNC Symbol)

Entrez gene summary

This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

Chromosome

6

Cytoband

q14.1

Chromosome location (bp)

80003887 - 80042527

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000112742 (version 78.38)

Entrez gene

7272

UniProt

P33981 (UniProt - Evidence at protein level)

neXtProt

NX_P33981

Antibodypedia

TTK antibodies


PROTEIN BROWSER

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ENST00000230510
 
ENST00000369798
 
ENST00000502580
 
ENST00000504040
 
ENST00000509894
 
ENST00000511260
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TTK-001 ENSP00000358813
ENST00000369798
P33981
Show all »
Show » Show » 857 97.1 No 0
TTK-002 ENSP00000230510
ENST00000230510
P33981
Show all »
Show » Show » 856 96.9 No 0
TTK-003 ENSP00000422936
ENST00000509894
P33981
Show all »
Show » Show » 856 96.9 No 0
TTK-004 ENSP00000421636
ENST00000511260
D6REX1
Show all »
Show » Show » 150 17.1 No 0
TTK-005 ENSP00000424851
ENST00000502580
D6RF82
Show all »
Show » Show » 139 15.8 No 0
TTK-006 ENSP00000427483
ENST00000504040
D6RIC6
Show all »
Show » Show » 176 19.9 No 0