NNT

GENERAL INFORMATION

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Gene name

NNT

Gene description

Nicotinamide nucleotide transhydrogenase

Protein class

Disease related genes
Enzymes
Mitochondrial proteins
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Granular cytoplasmic expression in most tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA004829 , CAB004975
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

NNT

Synonyms

Description

Nicotinamide nucleotide transhydrogenase (HGNC Symbol)

Entrez gene summary

This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. Two alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

p12

Chromosome location (bp)

43602692 - 43707405

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000112992 (version 78.38)

Entrez gene

23530

UniProt

Q13423 (UniProt - Evidence at protein level)

neXtProt

NX_Q13423

Antibodypedia

NNT antibodies


PROTEIN BROWSER

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ENST00000264663
 
ENST00000344920
 
ENST00000503651
 
ENST00000505678
 
ENST00000512422
 
ENST00000512996
 
ENST00000515208
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NNT-001 ENSP00000264663
ENST00000264663
Q13423
Show all »
Show » Show » 1086 113.9 No >9
NNT-002 ENSP00000343873
ENST00000344920
Q13423
Show all »
Show » Show » 1086 113.9 No >9
NNT-004 ENSP00000426343
ENST00000512996
E9PCX7
Show all »
Show » Show » 955 99.7 No >9
NNT-006 ENSP00000421886
ENST00000512422
D6RAI5
Show all »
Show » Show » 217 23.5 No 0
NNT-007 ENSP00000425542
ENST00000515208
D6RCR6
Show all »
Show » 58 6.4 No 0
NNT-010 ENSP00000421674
ENST00000503651
H0Y8P5
Show all »
Show » 57 6.1 No 0
NNT-012 ENSP00000427670
ENST00000505678
D6RHU2
Show all »
Show » Show » 199 21.5 No 0