GZMK

GENERAL INFORMATION

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Gene name

GZMK

Gene description

Granzyme K (granzyme 3; tryptase II)

Protein class

Enzymes
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (lymph node)
GTEx:Group enriched (small intestine, spleen)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in immune cells.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA063181
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (lymph node)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (small intestine, spleen)

Organ

Expression



GENE INFORMATION

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Gene name

GZMK (HGNC Symbol)

Synonyms

PRSS, TRYP2

Description

Granzyme K (granzyme 3; tryptase II) (HGNC Symbol)

Entrez gene summary

This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q11.2

Chromosome location (bp)

55024253 - 55034570

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000113088 (version 78.38)

Entrez gene

3003

UniProt

P49863 (UniProt - Evidence at protein level)

neXtProt

NX_P49863

Antibodypedia

GZMK antibodies


PROTEIN BROWSER

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ENST00000231009
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GZMK-001 ENSP00000231009
ENST00000231009
P49863
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