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FN1
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  • FN1
PROTEIN STRUCTURE
ANTIBODIES
AND
VALIDATION
Protein structures
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

FN1
Synonyms CIG, FINC, GFND2, LETS, MSF
Gene descriptioni

Full gene name according to HGNC.

Fibronectin 1
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Read more
Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
Human disease related genes
Plasma proteins
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.

  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Read more
Intracellular,Secreted
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Chromosome 2
Cytoband q35
Chromosome location (bp) 215360440 - 215436073
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

13
Ensembl ENSG00000115414 (version 103.38)
Entrez gene 2335
HGNC HGNC:3778
UniProt P02751 (UniProt - Evidence at protein level)
neXtProt NX_P02751
Antibodypedia FN1 antibodies


PROTEIN STRUCTUREi

The Structure section provides predicted structures from the Alphafold protein structure database and available experimental structures from Protein Data Bank (PDB).

In the Structure drop-down menu all experimental structures from PDB are available for selection and display. The structures are displayed using the NGL Viewer and can be zoomed-in and rotated either manually or by checking the Autorotate box. The Color scheme can be selected to show the residue index, chain name or confidence score (as B-factors and pLDDT score for experimental and predicted structures, respectively). The positions for available antigen sequences in the structure are shown if Antigens is turned to ON, and the Variants slider can be used to show the positions of clinical and population variants.https://github.com/nglviewer/ngl

Read more

Predicted


Description: Structure prediction from Alphafold project. Structure version 2

# Chains: 1      # Clinical variants: 6      # Population variants: 1377

Antigens:

Off
On

Variants:

Off
Clinical
Population

Color scheme:

Confidence
Residue index
Chain name

Autorotate:

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On



PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Below the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50). The region with the lowest possible identity is always selected for antigen design, with a maximum identity of 60% allowed for designing a single-target antigen (read more).

The curve in blue displays the predicted antigenicity i.e. the tendency for different regions of the protein to generate an immune response, with peak regions being predicted to be more antigenic.The curve shows average values based on a sliding window approach using an in-house propensity scale. (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.
«
FN1-201
FN1-202
FN1-203
FN1-204
FN1-205
FN1-206
FN1-207
FN1-208
FN1-209
FN1-210
FN1-211
FN1-212
FN1-213
»


PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant UniProt Protein class Gene ontology Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
FN1-201
ENSP00000323534
ENST00000323926
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008022 [protein C-terminus binding]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0010952 [positive regulation of peptidase activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0018149 [peptide cross-linking]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0042802 [identical protein binding]
GO:0043394 [proteoglycan binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0051087 [chaperone binding]
GO:0051702 [interaction with symbiont]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0097718 [disordered domain specific binding]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Show all
2446 aa
268.9 kDa
Yes 0
FN1-202
ENSP00000338200
ENST00000336916
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008022 [protein C-terminus binding]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0010952 [positive regulation of peptidase activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0018149 [peptide cross-linking]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0042802 [identical protein binding]
GO:0043394 [proteoglycan binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0051087 [chaperone binding]
GO:0051702 [interaction with symbiont]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0097718 [disordered domain specific binding]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Show all
2355 aa
259.2 kDa
Yes 0
FN1-203
ENSP00000346839
ENST00000354785
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007161 [calcium-independent cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008022 [protein C-terminus binding]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0010952 [positive regulation of peptidase activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016324 [apical plasma membrane]
GO:0016504 [peptidase activator activity]
GO:0018149 [peptide cross-linking]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0042060 [wound healing]
GO:0042802 [identical protein binding]
GO:0043394 [proteoglycan binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045773 [positive regulation of axon extension]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0051087 [chaperone binding]
GO:0051702 [interaction with symbiont]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0097718 [disordered domain specific binding]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Show all
2477 aa
272.3 kDa
Yes 0
FN1-204
ENSP00000348285
ENST00000356005
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008022 [protein C-terminus binding]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0010952 [positive regulation of peptidase activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0018149 [peptide cross-linking]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0042802 [identical protein binding]
GO:0043394 [proteoglycan binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0051087 [chaperone binding]
GO:0051702 [interaction with symbiont]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0097718 [disordered domain specific binding]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Show all
2296 aa
252.8 kDa
Yes 0
FN1-205
ENSP00000350534
ENST00000357867
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008022 [protein C-terminus binding]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0010952 [positive regulation of peptidase activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0018149 [peptide cross-linking]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0042802 [identical protein binding]
GO:0043394 [proteoglycan binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0051087 [chaperone binding]
GO:0051702 [interaction with symbiont]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0097718 [disordered domain specific binding]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Show all
2176 aa
239.6 kDa
Yes 0
FN1-206
ENSP00000352696
ENST00000359671
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008022 [protein C-terminus binding]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0010952 [positive regulation of peptidase activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0018149 [peptide cross-linking]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0042802 [identical protein binding]
GO:0043394 [proteoglycan binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0051087 [chaperone binding]
GO:0051702 [interaction with symbiont]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0097718 [disordered domain specific binding]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Show all
2386 aa
262.6 kDa
Yes 0
FN1-207
ENSP00000394423
ENST00000421182
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008022 [protein C-terminus binding]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0010952 [positive regulation of peptidase activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0018149 [peptide cross-linking]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0042802 [identical protein binding]
GO:0043394 [proteoglycan binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0051087 [chaperone binding]
GO:0051702 [interaction with symbiont]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0097718 [disordered domain specific binding]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Show all
2240 aa
246.7 kDa
Yes 0
FN1-208
ENSP00000398907
ENST00000426059
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008022 [protein C-terminus binding]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0010952 [positive regulation of peptidase activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0018149 [peptide cross-linking]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0042802 [identical protein binding]
GO:0043394 [proteoglycan binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0051087 [chaperone binding]
GO:0051702 [interaction with symbiont]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0097718 [disordered domain specific binding]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Show all
657 aa
73.7 kDa
Yes 0
FN1-209
ENSP00000399538
ENST00000432072
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008022 [protein C-terminus binding]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0010952 [positive regulation of peptidase activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0018149 [peptide cross-linking]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0042802 [identical protein binding]
GO:0043394 [proteoglycan binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0051087 [chaperone binding]
GO:0051702 [interaction with symbiont]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0097718 [disordered domain specific binding]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Show all
2267 aa
249.3 kDa
Yes 0
FN1-210
ENSP00000392565
ENST00000438981
H0Y4K8 [Direct mapping]
Fibronectin
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutational cancer driver genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
241 aa
26.6 kDa
No 0
FN1-211
ENSP00000415018
ENST00000443816
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008022 [protein C-terminus binding]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0010952 [positive regulation of peptidase activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0018149 [peptide cross-linking]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0042802 [identical protein binding]
GO:0043394 [proteoglycan binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0051087 [chaperone binding]
GO:0051702 [interaction with symbiont]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0097718 [disordered domain specific binding]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Show all
2265 aa
249.4 kDa
Yes 0
FN1-212
ENSP00000410422
ENST00000446046
P02751 [Direct mapping]
Fibronectin Anastellin Ugl-Y1 Ugl-Y2 Ugl-Y3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Biotech drugs
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001932 [regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002576 [platelet degranulation]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005201 [extracellular matrix structural constituent]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005577 [fibrinogen complex]
GO:0005615 [extracellular space]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0006953 [acute-phase response]
GO:0007044 [cell-substrate junction assembly]
GO:0007155 [cell adhesion]
GO:0007160 [cell-matrix adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007399 [nervous system development]
GO:0007507 [heart development]
GO:0008022 [protein C-terminus binding]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell population proliferation]
GO:0008360 [regulation of cell shape]
GO:0009611 [response to wounding]
GO:0010628 [positive regulation of gene expression]
GO:0010952 [positive regulation of peptidase activity]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0018149 [peptide cross-linking]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019899 [enzyme binding]
GO:0030198 [extracellular matrix organization]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0033622 [integrin activation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035987 [endodermal cell differentiation]
GO:0042802 [identical protein binding]
GO:0043394 [proteoglycan binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050900 [leukocyte migration]
GO:0051087 [chaperone binding]
GO:0051702 [interaction with symbiont]
GO:0062023 [collagen-containing extracellular matrix]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:0071635 [negative regulation of transforming growth factor beta production]
GO:0072378 [blood coagulation, fibrin clot formation]
GO:0072562 [blood microparticle]
GO:0097718 [disordered domain specific binding]
GO:1901166 [neural crest cell migration involved in autonomic nervous system development]
GO:1904237 [positive regulation of substrate-dependent cell migration, cell attachment to substrate]
Show all
2330 aa
256.5 kDa
Yes 0
FN1-213
ENSP00000416139
ENST00000456923
H0Y7Z1 [Direct mapping]
Fibronectin
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutational cancer driver genes
Human disease related genes
   Congenital malformations
   Congenital malformations of the musculoskeletal system
   Urinary system diseases
   Kidney diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0006953 [acute-phase response]
GO:0008201 [heparin binding]
GO:0008360 [regulation of cell shape]
Show all
1103 aa
120.8 kDa
No 0

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