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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
2
Cytoband
q35
Chromosome location (bp)
216672105 - 216695549
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Growth factor binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables insulin-like growth factor I binding activity. Involved in several processes, including cellular response to cAMP; regulation of smooth muscle cell migration; and regulation of smooth muscle cell proliferation. Part of insulin-like growth factor ternary complex. Biomarker of pulmonary fibrosis. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
P24593 [Direct mapping] Insulin-like growth factor-binding protein 5
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MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001558[regulation of cell growth] GO:0001649[osteoblast differentiation] GO:0001968[fibronectin binding] GO:0005515[protein binding] GO:0005520[insulin-like growth factor binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005788[endoplasmic reticulum lumen] GO:0007165[signal transduction] GO:0007565[female pregnancy] GO:0007568[aging] GO:0014070[response to organic cyclic compound] GO:0014912[negative regulation of smooth muscle cell migration] GO:0016942[insulin-like growth factor binding protein complex] GO:0017148[negative regulation of translation] GO:0019838[growth factor binding] GO:0030336[negative regulation of cell migration] GO:0031069[hair follicle morphogenesis] GO:0031994[insulin-like growth factor I binding] GO:0031995[insulin-like growth factor II binding] GO:0035556[intracellular signal transduction] GO:0040008[regulation of growth] GO:0042567[insulin-like growth factor ternary complex] GO:0042593[glucose homeostasis] GO:0043567[regulation of insulin-like growth factor receptor signaling pathway] GO:0043568[positive regulation of insulin-like growth factor receptor signaling pathway] GO:0043569[negative regulation of insulin-like growth factor receptor signaling pathway] GO:0044342[type B pancreatic cell proliferation] GO:0045668[negative regulation of osteoblast differentiation] GO:0045926[negative regulation of growth] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048286[lung alveolus development] GO:0048662[negative regulation of smooth muscle cell proliferation] GO:0050896[response to stimulus] GO:0051146[striated muscle cell differentiation] GO:0051897[positive regulation of protein kinase B signaling] GO:0060056[mammary gland involution] GO:0060416[response to growth hormone] GO:0071320[cellular response to cAMP] GO:0071407[cellular response to organic cyclic compound] GO:1901862[negative regulation of muscle tissue development] GO:1904205[negative regulation of skeletal muscle hypertrophy] GO:1904707[positive regulation of vascular associated smooth muscle cell proliferation] GO:1904754[positive regulation of vascular associated smooth muscle cell migration]