ATP6V0B

GENERAL INFORMATION

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Gene name

ATP6V0B

Gene description

ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b

Protein class

Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at transcript level

Protein localization

RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.

Data reliability

Uncertain based on 1 antibody.
HPA044281
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Endometrium



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ATP6V0B (HGNC Symbol)

Synonyms

ATP6F, HATPL, VMA16

Description

ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (HGNC Symbol)

Entrez gene summary

This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Chromosome

1

Cytoband

p34.1

Chromosome location (bp)

43974487 - 43978295

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000117410 (version 78.38)

Entrez gene

533

UniProt

Q99437 (UniProt - Evidence at transcript level)

neXtProt

NX_Q99437

Antibodypedia

ATP6V0B antibodies


PROTEIN BROWSER

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ENST00000236067
 
ENST00000471859
 
ENST00000472174
 
ENST00000472505
 
ENST00000498664
 
ENST00000532642
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP6V0B-001 ENSP00000431605
ENST00000472174
Q99437
Show all »
Show » Show » 205 21.4 No 5
ATP6V0B-004 ENSP00000236067
ENST00000236067
Q99437
Show all »
Show » Show » 158 16.2 No 3
ATP6V0B-006 ENSP00000432754
ENST00000471859
E9PNU0
Show all »
Show » Show » 252 26.1 Yes 4
ATP6V0B-011 ENSP00000434094
ENST00000498664
Q99437
Show all »
Show » Show » 158 16.2 No 3
ATP6V0B-012 ENSP00000434729
ENST00000532642
E9PNL3
Show all »
Show » Show » 261 27.7 No 5
ATP6V0B-013 ENSP00000432994
ENST00000472505
E9PMR1
Show all »
Show » Show » 86 9 No 2