CCND2

GENERAL INFORMATION

? »

Gene name

CCND2

Gene description

Cyclin D2

Protein class

Cancer-related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Moderate cytoplasmic and/or nuclear positivity was displayed in gastrointestinal glands, heart myocytes, epididymis and Purkinje cells. Superficial layers of squamous epithelial cells and renal tubules showed moderate membranous and cytoplasmic immunoreactivity. Remaining normal tissues were weakly stained or negative.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA049138
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Thyroid gland

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

? »

Gene name

CCND2

Synonyms

Description

Cyclin D2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]

Chromosome

12

Cytoband

p13.32

Chromosome location (bp)

4273772 - 4305350

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000118971 (version 78.38)

Entrez gene

894

UniProt

P30279 (UniProt - Evidence at protein level)

neXtProt

NX_P30279

Antibodypedia

CCND2 antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000261254
 
ENST00000536537
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCND2-001 ENSP00000261254
ENST00000261254
P30279
Show all »
Show » Show » 289 33.1 No 0
CCND2-004 ENSP00000442807
ENST00000536537
Show » 170 19 No 0