DNMT3A

GENERAL INFORMATION

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Gene name

DNMT3A

Gene description

DNA (cytosine-5-)-methyltransferase 3 alpha

Protein class

Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

5
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Ubiquitous nuclear expression, in several cases accompanied by cytoplasmic expression.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA026588 , CAB009469
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

DNMT3A

Synonyms

Description

DNA (cytosine-5-)-methyltransferase 3 alpha (HGNC Symbol)

Entrez gene summary

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p23.3

Chromosome location (bp)

25227855 - 25342590

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000119772 (version 78.38)

Entrez gene

1788

UniProt

Q9Y6K1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y6K1

Antibodypedia

DNMT3A antibodies


PROTEIN BROWSER

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ENST00000264709
 
ENST00000321117
 
ENST00000380746
 
ENST00000402667
 
ENST00000406659
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DNMT3A-001 ENSP00000264709
ENST00000264709
Q9Y6K1
Show all »
Show » Show » 912 101.9 No 0
DNMT3A-002 ENSP00000370122
ENST00000380746
Q9Y6K1
Show all »
Show » Show » 723 81.6 No 0
DNMT3A-011 ENSP00000324375
ENST00000321117
Q9Y6K1
Show all »
Show » Show » 912 101.9 No 0
DNMT3A-012 ENSP00000384852
ENST00000406659
Q9Y6K1
Show all »
Show » Show » 166 16.9 No 0
DNMT3A-013 ENSP00000384237
ENST00000402667
Q9Y6K1
Show all »
Show » Show » 689 77.8 No 0