BCL11A

GENERAL INFORMATION

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Gene name

BCL11A

Gene description

B-cell CLL/lymphoma 11A (zinc finger protein)

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression mainly in leukocytes, respiratory and squamous epithelia, urothelium and neuronal cells.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
HPA029003 , CAB014891
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

BCL11A (HGNC Symbol)

Synonyms

BCL11A-L, BCL11A-S, BCL11A-XL, CTIP1, EVI9, HBFQTL5, ZNF856

Description

B-cell CLL/lymphoma 11A (zinc finger protein) (HGNC Symbol)

Entrez gene summary

This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p16.1

Chromosome location (bp)

60451167 - 60553567

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000119866 (version 78.38)

Entrez gene

53335

UniProt

Q9H165 (UniProt - Evidence at protein level)

neXtProt

NX_Q9H165

Antibodypedia

BCL11A antibodies


PROTEIN BROWSER

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ENST00000335712
 
ENST00000356842
 
ENST00000358510
 
ENST00000359629
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCL11A-001 ENSP00000338774
ENST00000335712
Q9H165
Show all »
Show » Show » 835 91.2 No 0
BCL11A-002 ENSP00000349300
ENST00000356842
Q9H165
Show all »
Show » Show » 773 83.9 No 0
BCL11A-003 ENSP00000352648
ENST00000359629
Q9H165
Show all »
Show » Show » 243 26.9 No 0
BCL11A-006 ENSP00000351307
ENST00000358510
Q9H165
Show all »
Show » Show » 801 87.6 No 0