TBX4

GENERAL INFORMATION

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Gene name

TBX4

Gene description

T-box 4

Protein class

Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Group enriched (lung, placenta, prostate)
GTEx:Group enriched (lung, prostate, urinary bladder)

Protein evidence

Evidence at protein level

Protein localization

RNA data suggests expression mainly in lung and placenta. RNA-based expert annotation gave inconclusive results.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Data reliability

Uncertain based on 1 antibody.
CAB032413
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Kidney & urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
N/A
Prostate
N/A
Seminal vesicle
N/A
N/A
Female tissues
N/A
Breast
N/A
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.


RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Group enriched (lung, placenta, prostate)

Organ

Expression

GTEx dataset
RNA tissue category:  Group enriched (lung, prostate, urinary bladder)

Organ

Expression



GENE INFORMATION

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Gene name

TBX4

Synonyms

Description

T-box 4 (HGNC Symbol)

Entrez gene summary

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly this gene, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for this gene in regulating limb development and specification of limb identity. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q23.2

Chromosome location (bp)

61452404 - 61485110

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000121075 (version 78.38)

Entrez gene

9496

UniProt

P57082 (UniProt - Evidence at protein level)

neXtProt

NX_P57082

Antibodypedia

TBX4 antibodies


PROTEIN BROWSER

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ENST00000240335
 
ENST00000393853
 
ENST00000589003
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TBX4-001 ENSP00000377435
ENST00000393853
P57082
Show all »
Show » Show » 546 60.3 No 0
TBX4-002 ENSP00000240335
ENST00000240335
P57082
Show all »
Show » Show » 545 60.2 No 0
TBX4-003 ENSP00000467588
ENST00000589003
K7EPY2
Show all »
Show » Show » 135 15.5 No 0