FLT3

GENERAL INFORMATION

? »

Gene name

FLT3

Gene description

Fms-related tyrosine kinase 3

Protein class

Cancer-related genes
CD markers
Disease related genes
Enzymes
FDA approved drug targets
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Tissue enhanced (lymph node, spleen)
GTEx:Tissue enhanced (cerebellum)

Protein evidence

Evidence at protein level

Protein localization

Normal tissues displayed moderate to strong cytoplasmic positivity with a granular pattern.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
CAB018358
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Tissue enhanced (lymph node, spleen)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (cerebellum)

Organ

Expression



GENE INFORMATION

? »

Gene name

FLT3 (HGNC Symbol)

Synonyms

CD135, FLK2, STK1

Description

Fms-related tyrosine kinase 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008]

Chromosome

13

Cytoband

q12.2

Chromosome location (bp)

28003274 - 28100592

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000122025 (version 78.38)

Entrez gene

2322

UniProt

P36888 (UniProt - Evidence at protein level)

neXtProt

NX_P36888

Antibodypedia

FLT3 antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000241453
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FLT3-001 ENSP00000241453
ENST00000241453
P36888
Show all »
Show » Show » 993 112.9 No 1