ITIH5

GENERAL INFORMATION

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Gene name

ITIH5

Gene description

Inter-alpha-trypsin inhibitor heavy chain family, member 5

Protein class

Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (placenta)
GTEx:Tissue enhanced (adipose tissue)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in most cell types.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
HPA038305
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (placenta)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (adipose tissue)

Organ

Expression



GENE INFORMATION

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Gene name

ITIH5 (HGNC Symbol)

Synonyms

MGC10848

Description

Inter-alpha-trypsin inhibitor heavy chain family, member 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Chromosome

10

Cytoband

p14

Chromosome location (bp)

7559270 - 7666998

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000123243 (version 78.38)

Entrez gene

80760

UniProt

neXtProt

Antibodypedia

ITIH5 antibodies


PROTEIN BROWSER

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ENST00000397145
 
ENST00000397146
 
ENST00000613909
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ITIH5-001 ENSP00000380333
ENST00000397146
Show » Show » 942 104.5 Yes 0
ITIH5-003 ENSP00000485414
ENST00000613909
Show » Show » 728 80.6 No 0
ITIH5-201 ENSP00000380332
ENST00000397145
G5E9D8
Show all »
Show » 702 78.4 Yes 0