MMP19

GENERAL INFORMATION

? »

Gene name

MMP19

Gene description

Matrix metallopeptidase 19

Protein class

Disease related genes
Enzymes
FDA approved drug targets
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

? »

RNA tissue category

HPA:Tissue enhanced (gallbladder)
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Subsets of cells in bone marrow and spleen showed strong cytoplasmic and nuclear positivity. Normal tissues in general were weakly stained or negative.

ANTIBODY RELIABILITY

? »

Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA012845
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

? »
RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

? »

Organ

Expression



RNA EXPRESSION OVERVIEW

? »
HPA dataset
RNA tissue category:  Tissue enhanced (gallbladder)

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

? »

Gene name

MMP19 (HGNC Symbol)

Synonyms

MMP18, RASI-1

Description

Matrix metallopeptidase 19 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

Chromosome

12

Cytoband

q13.2

Chromosome location (bp)

55835433 - 55842966

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000123342 (version 78.38)

Entrez gene

4327

UniProt

Q99542 (UniProt - Evidence at protein level)

neXtProt

NX_Q99542

Antibodypedia

MMP19 antibodies


PROTEIN BROWSER

? »
 
 
 
ENST00000322569
 
ENST00000409200
 
ENST00000548629
 
 
 
 


PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MMP19-001 ENSP00000313437
ENST00000322569
Q99542
Show all »
Show » Show » 508 57.4 Yes 0
MMP19-005 ENSP00000386625
ENST00000409200
Q99542
Show all »
Show » Show » 305 33.8 Yes 0
MMP19-011 ENSP00000446979
ENST00000548629
F8W1C3
Show all »
Show » Show » 485 54.6 Yes 0