PFKFB2

GENERAL INFORMATION

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Gene name

PFKFB2

Gene description

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Moderate to strong cytoplasmic staining was observed in gastrointestinal glands, islets of Langerhans, nasopharynx, renal tubules, melanocytes, subsets of lymphoid cells and glial cells. Remaining normal tissues were generally negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA049975
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PFKFB2

Synonyms

Description

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q32.1

Chromosome location (bp)

207034366 - 207081024

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000123836 (version 78.38)

Entrez gene

5208

UniProt

O60825 (UniProt - Evidence at protein level)

neXtProt

NX_O60825

Antibodypedia

PFKFB2 antibodies


PROTEIN BROWSER

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ENST00000367079
 
ENST00000367080
 
ENST00000545806
 
ENST00000618513
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PFKFB2-001 ENSP00000356047
ENST00000367080
O60825
Show all »
Show » Show » 505 58.5 No 0
PFKFB2-002 ENSP00000356046
ENST00000367079
O60825
Show all »
Show » Show » 471 54.4 No 0
PFKFB2-009 ENSP00000484988
ENST00000618513
Show » 49 5.4 No 0
PFKFB2-010 ENSP00000439420
ENST00000545806
Show » Show » 125 14.3 No 0