PEX6

GENERAL INFORMATION

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Gene name

PEX6

Gene description

Peroxisomal biogenesis factor 6

Protein class

Disease related genes
Potential drug targets
Predicted intracellular proteins
Transporters

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

General cytoplasmic expression with a granular pattern.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
HPA025924
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PEX6 (HGNC Symbol)

Synonyms

PAF-2, PXAAA1

Description

Peroxisomal biogenesis factor 6 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) family of ATPases. This member is a predominantly cytoplasmic protein, which plays a direct role in peroxisomal protein import and is required for PTS1 (peroxisomal targeting signal 1, a C-terminal tripeptide of the sequence ser-lys-leu) receptor activity. Mutations in this gene cause peroxisome biogenesis disorders of complementation group 4 and complementation group 6. [provided by RefSeq, Oct 2008]

Chromosome

6

Cytoband

p21.1

Chromosome location (bp)

42963870 - 42979220

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000124587 (version 78.38)

Entrez gene

5190

UniProt

Q13608 (UniProt - Evidence at protein level)

neXtProt

NX_Q13608

Antibodypedia

PEX6 antibodies


PROTEIN BROWSER

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ENST00000244546
 
ENST00000304611
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PEX6-001 ENSP00000303511
ENST00000304611
Q13608
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Show » Show » 980 104.1 No 0
PEX6-201 ENSP00000244546
ENST00000244546
Q8WYQ0
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Show » Show » 738 77.7 No 0