UPF3B

GENERAL INFORMATION

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Gene name

UPF3B

Gene description

UPF3 regulator of nonsense transcripts homolog B (yeast)

Protein class

Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in most tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Supportive based on 2 antibodies.
HPA001800 , HPA001882
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

UPF3B (HGNC Symbol)

Synonyms

HUPF3B, MRX62, RENT3B, UPF3X

Description

UPF3 regulator of nonsense transcripts homolog B (yeast) (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

q24

Chromosome location (bp)

119834022 - 119852998

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000125351 (version 78.38)

Entrez gene

65109

UniProt

Q9BZI7 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BZI7

Antibodypedia

UPF3B antibodies


PROTEIN BROWSER

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ENST00000276201
 
ENST00000345865
 
ENST00000619445
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UPF3B-001 ENSP00000276201
ENST00000276201
Q9BZI7
Show all »
Show » Show » 483 57.8 No 0
UPF3B-002 ENSP00000245418
ENST00000345865
Q9BZI7
Show all »
Show » Show » 470 56.2 No 0
UPF3B-201 ENSP00000481698
ENST00000619445
Show » 217 25.2 No 0