UROD

GENERAL INFORMATION

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Gene name

UROD

Gene description

Uroporphyrinogen decarboxylase

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Distinct cytoplasmic and membranous expression in glandular cells

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
HPA027468 , HPA028668
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Epididymis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

UROD

Synonyms

Description

Uroporphyrinogen decarboxylase (HGNC Symbol)

Entrez gene summary

This gene encodes an enzyme in the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.[provided by RefSeq, Aug 2010]

Chromosome

1

Cytoband

p34.1

Chromosome location (bp)

45012147 - 45015575

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000126088 (version 78.38)

Entrez gene

7389

UniProt

P06132 (UniProt - Evidence at protein level)

neXtProt

NX_P06132

Antibodypedia

UROD antibodies


PROTEIN BROWSER

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ENST00000246337
 
ENST00000428106
 
ENST00000434478
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UROD-001 ENSP00000246337
ENST00000246337
P06132
Show all »
Show » Show » 367 40.8 No 0
UROD-003 ENSP00000400253
ENST00000428106
Show » Show » 228 25.3 No 0
UROD-004 ENSP00000404489
ENST00000434478
Q5T446
Show all »
Show » Show » 193 21.5 No 0