BCL2L12

GENERAL INFORMATION

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Gene name

BCL2L12

Gene description

BCL2-like 12 (proline rich)

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

10
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Normal tissues generally showed moderate cytoplasmic staining. The adrenal gland, decidual and leydig cells exhibited strong cytoplasmic staining. Alveolar cells, renal glomeruli, cells in CNS and ovarian follicles were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA020856
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

BCL2L12

Synonyms

Description

BCL2-like 12 (proline rich) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Chromosome

19

Cytoband

q13.33

Chromosome location (bp)

49665142 - 49673916

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000126453 (version 78.38)

Entrez gene

83596

UniProt

Q9HB09 (UniProt - Evidence at protein level)

neXtProt

NX_Q9HB09

Antibodypedia

BCL2L12 antibodies


PROTEIN BROWSER

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ENST00000246784
 
ENST00000246785
 
ENST00000441864
 
ENST00000594157
 
ENST00000598306
 
ENST00000600947
 
ENST00000611631
 
ENST00000614495
 
ENST00000616144
 
ENST00000619007
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BCL2L12-001 ENSP00000246785
ENST00000246785
Q9HB09
Show all »
Show » Show » 334 36.8 No 0
BCL2L12-002 ENSP00000393803
ENST00000441864
Show » 333 36.7 No 0
BCL2L12-004 ENSP00000469216
ENST00000594157
M0R1K0
Show all »
Show » 92 9.2 No 0
BCL2L12-006 ENSP00000470644
ENST00000600947
Show » 138 14.7 No 0
BCL2L12-008 ENSP00000472214
ENST00000598306
M0R1Z8
Show all »
Show » 92 10 No 0
BCL2L12-009 ENSP00000246784
ENST00000246784
Show » 250 26.9 No 0
BCL2L12-201 ENSP00000478415
ENST00000611631
I6LK00
Show all »
Show » 130 15 No 0
BCL2L12-202 ENSP00000482154
ENST00000614495
I6LJZ9
Show all »
Show » 193 21.4 No 0
BCL2L12-203 ENSP00000482218
ENST00000616144
Q9HB09
Show all »
Show » Show » 334 36.8 No 0
BCL2L12-204 ENSP00000483272
ENST00000619007
I6LJZ7
Show all »
Show » 269 29.9 No 0