PIN1

GENERAL INFORMATION

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Gene name

PIN1

Gene description

Peptidylprolyl cis/trans isomerase, NIMA-interacting 1

Protein class

Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Nuclear and cytoplasmic expression in several tissues with highest levels in neuronal cells of cns.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 2 antibodies.
CAB004528 , CAB009326
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

PIN1 (HGNC Symbol)

Synonyms

dod

Description

Peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (HGNC Symbol)

Entrez gene summary

Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]

Chromosome

19

Cytoband

p13.2

Chromosome location (bp)

9835257 - 9849682

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000127445 (version 78.38)

Entrez gene

5300

UniProt

Q13526 (UniProt - Evidence at protein level)

neXtProt

NX_Q13526

Antibodypedia

PIN1 antibodies


PROTEIN BROWSER

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ENST00000247970
 
ENST00000587625
 
ENST00000588695
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PIN1-001 ENSP00000247970
ENST00000247970
Q13526
Show all »
Show » Show » 163 18.2 No 0
PIN1-007 ENSP00000466656
ENST00000587625
K7EMU7
Show all »
Show » Show » 145 16.1 No 0
PIN1-008 ENSP00000466962
ENST00000588695
Q13526
Show all »
Show » Show » 163 18.2 No 0