ADM2

GENERAL INFORMATION

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Gene name

ADM2

Gene description

Adrenomedullin 2

Protein class

Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (thyroid gland)
GTEx:Tissue enhanced (thyroid gland)

Protein evidence

Evidence at transcript level

Protein localization

Normal tissues showed weak to moderate cytoplasmic and nuclear/nucleolar staining. Lung macrophages and skeletal muscle displayed strong cytoplasmic positivity. Respiratory epithelium of nasopharynx, purkinje cells, squamous epithelium of vagina and adrenal glad exhibited strong nuclear and cytoplasmic immunoreactivity. Bile duct cells, parathyroid, lymphoid tissues and glial cells were mainly negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA039691
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (thyroid gland)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (thyroid gland)

Organ

Expression



GENE INFORMATION

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Gene name

ADM2 (HGNC Symbol)

Synonyms

AM2, FLJ21135

Description

Adrenomedullin 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein which is a member of the calcitonin-related hormones. The encoded protein is involved in maintaining homeostasis in many tissues, acting via CRLR/RAMP receptor (calcitonin receptor-like receptor/receptor activity-modifying protein) complexes. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

Chromosome

22

Cytoband

q13.33

Chromosome location (bp)

50481556 - 50486440

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000128165 (version 78.38)

Entrez gene

79924

UniProt

Q7Z4H4 (UniProt - Evidence at transcript level)

neXtProt

NX_Q7Z4H4

Antibodypedia

ADM2 antibodies


PROTEIN BROWSER

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ENST00000395737
 
ENST00000395738
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADM2-001 ENSP00000379087
ENST00000395738
Q7Z4H4
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Show » Show » 148 15.9 Yes 0
ADM2-002 ENSP00000379086
ENST00000395737
Q7Z4H4
Show all »
Show » Show » 148 15.9 Yes 0