SNRPN

GENERAL INFORMATION

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Gene name

SNRPN

Gene description

Small nuclear ribonucleoprotein polypeptide N

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

9
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Mixed

Protein evidence

Evidence at protein level

Protein localization

Nuclear expression in the CNS.

ANTIBODY RELIABILITY

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Data reliability
description

Caution, targets protein from more than one gene. External characterization data supports antibody staining.

Data reliability

Uncertain based on 1 antibody.
HPA003482
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lateral ventricle

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Mixed

Organ

Expression



GENE INFORMATION

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Gene name

SNRPN (HGNC Symbol)

Synonyms

HCERN3, PWCR, RT-LI, SM-D, SMN, SNRNP-N, SNURF-SNRPN

Description

Small nuclear ribonucleoprotein polypeptide N (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. [provided by RefSeq, Jul 2008]

Chromosome

15

Cytoband

q11.2

Chromosome location (bp)

24823647 - 24978723

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000128739 (version 78.38)

Entrez gene

6638

UniProt

P63162 (UniProt - Evidence at protein level)

neXtProt

NX_P63162

Antibodypedia

SNRPN antibodies


PROTEIN BROWSER

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ENST00000346403
 
ENST00000390687
 
ENST00000400097
 
ENST00000400098
 
ENST00000400100
 
ENST00000554227
 
ENST00000577565
 
ENST00000579070
 
ENST00000584968
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SNRPN-001 ENSP00000375105
ENST00000390687
P63162
Show all »
Show » Show » 240 24.6 No 0
SNRPN-002 ENSP00000452342
ENST00000554227
P63162
Show all »
Show » Show » 244 25.1 No 0
SNRPN-003 ENSP00000382972
ENST00000400100
P63162
Show all »
Show » Show » 240 24.6 No 0
SNRPN-004 ENSP00000382969
ENST00000400097
P63162
Show all »
Show » Show » 240 24.6 No 0
SNRPN-006 ENSP00000463510
ENST00000579070
J3QLE5
Show all »
Show » 169 17.5 No 0
SNRPN-007 ENSP00000306223
ENST00000346403
P63162
Show all »
Show » Show » 240 24.6 No 0
SNRPN-008 ENSP00000463458
ENST00000577565
P63162
Show all »
Show » Show » 240 24.6 No 0
SNRPN-009 ENSP00000462211
ENST00000584968
J3KRY3
Show all »
Show » 59 7 No 0
SNRPN-201 ENSP00000382970
ENST00000400098
P63162
Show all »
Show » Show » 240 24.6 No 0