TTBK2

GENERAL INFORMATION

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Gene name

TTBK2

Gene description

Tau tubulin kinase 2

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

7
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (testis)
GTEx:Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein localization

Cytoplasmic expression in several tissues including cilia in fallopian tube.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.

Data reliability

Uncertain based on 2 antibodies.
HPA018113 , HPA049866
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression



GENE INFORMATION

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Gene name

TTBK2 (HGNC Symbol)

Synonyms

KIAA0847, SCA11

Description

Tau tubulin kinase 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009]

Chromosome

15

Cytoband

q15.2

Chromosome location (bp)

42738734 - 42920809

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000128881 (version 78.38)

Entrez gene

146057

UniProt

Q6IQ55 (UniProt - Evidence at protein level)

neXtProt

NX_Q6IQ55

Antibodypedia

TTBK2 antibodies


PROTEIN BROWSER

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ENST00000267890
 
ENST00000562880
 
ENST00000564431
 
ENST00000566931
 
ENST00000567274
 
ENST00000567840
 
ENST00000622375
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TTBK2-001 ENSP00000267890
ENST00000267890
Q6IQ55
Show all »
Show » Show » 1244 137.4 No 0
TTBK2-002 ENSP00000455734
ENST00000567840
Q6IQ55
Show all »
Show » Show » 478 54 No 0
TTBK2-003 ENSP00000457489
ENST00000567274
H3BTY5
Show all »
Show » Show » 443 50.1 No 0
TTBK2-006 ENSP00000457385
ENST00000562880
H3BTY5
Show all »
Show » Show » 143 16.1 No 0
TTBK2-007 ENSP00000455574
ENST00000564431
H3BQ25
Show all »
Show » 117 12.8 No 0
TTBK2-008 ENSP00000454605
ENST00000566931
H3BMY7
Show all »
Show » 84 9.2 No 0
TTBK2-201 ENSP00000479984
ENST00000622375
Q8IWY7
Show all »
Show » Show » 1649 182.5 No 0