CDKN2D

GENERAL INFORMATION

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Gene name

CDKN2D

Gene description

Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Nuclear and cytoplasmic expression mainly in testis and bone marrow.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Supportive based on 1 antibody.
CAB011201
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

CDKN2D (HGNC Symbol)

Synonyms

INK4D, p19

Description

Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

p13.2

Chromosome location (bp)

10566462 - 10569059

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000129355 (version 78.38)

Entrez gene

1032

UniProt

P55273 (UniProt - Evidence at protein level)

neXtProt

NX_P55273

Antibodypedia

CDKN2D antibodies


PROTEIN BROWSER

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ENST00000335766
 
ENST00000393599
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDKN2D-001 ENSP00000377224
ENST00000393599
P55273
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Show » Show » 166 17.7 No 0
CDKN2D-002 ENSP00000337056
ENST00000335766
P55273
Show all »
Show » Show » 166 17.7 No 0