KLK14

GENERAL INFORMATION

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Gene name

KLK14

Gene description

Kallikrein-related peptidase 14

Protein class

Cancer-related genes
Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enriched (skin)
GTEx:Tissue enhanced (skin)

Protein evidence

Evidence at protein level

Protein localization

Extracellular deposits and cytoplasmic expression in most tissues.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Data reliability

Uncertain based on 1 antibody.
CAB026228
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enriched (skin)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enhanced (skin)

Organ

Expression



GENE INFORMATION

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Gene name

KLK14 (HGNC Symbol)

Synonyms

KLK-L6

Description

Kallikrein-related peptidase 14 (HGNC Symbol)

Entrez gene summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. An additional transcript variant has been described but its full length nature has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.41

Chromosome location (bp)

51077495 - 51084245

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000129437 (version 78.38)

Entrez gene

43847

UniProt

Q9P0G3 (UniProt - Evidence at protein level)

neXtProt

NX_Q9P0G3

Antibodypedia

KLK14 antibodies


PROTEIN BROWSER

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ENST00000156499
 
ENST00000391802
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KLK14-001 ENSP00000156499
ENST00000156499
Q9P0G3
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Show » Show » 267 29.1 Yes 0
KLK14-201 ENSP00000375678
ENST00000391802
Q9P0G3
Show all »
Show » Show » 267 29.1 Yes 0