AANAT

GENERAL INFORMATION

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Gene name

AANAT

Gene description

Aralkylamine N-acetyltransferase

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Tissue enhanced (testis)
GTEx:Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein localization

Moderate cytoplasmic positivity was observed in gastro-intestinal glands, renal tubules, cells in seminiferus ducts of testis, neuronal cells, hematopoietic cells and myocytes. Hepatocytes were strongly stained. Remaining normal tissues were weakly stained or negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA050784
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Tissue enhanced (testis)

Organ

Expression

GTEx dataset
RNA tissue category:  Tissue enriched (testis)

Organ

Expression



GENE INFORMATION

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Gene name

AANAT (HGNC Symbol)

Synonyms

SNAT

Description

Aralkylamine N-acetyltransferase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Chromosome

17

Cytoband

q25.1

Chromosome location (bp)

76453351 - 76470117

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000129673 (version 78.38)

Entrez gene

15

UniProt

Q16613 (UniProt - Evidence at protein level)

neXtProt

NX_Q16613

Antibodypedia

AANAT antibodies


PROTEIN BROWSER

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ENST00000250615
 
ENST00000392492
 
ENST00000585649
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AANAT-001 ENSP00000250615
ENST00000250615
Q16613
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Show » Show » 252 28.4 No 0
AANAT-002 ENSP00000376282
ENST00000392492
Q16613
Show all »
Show » Show » 207 23.3 No 0
AANAT-004 ENSP00000468717
ENST00000585649
K7ESH7
Show all »
Show » 152 17.2 Yes 0