ATG4D

GENERAL INFORMATION

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Gene name

ATG4D

Gene description

Autophagy related 4D, cysteine peptidase

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

6
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Mixed
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Mainly cytoplasmic expression in several different tissue types.

ANTIBODY RELIABILITY

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Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Data reliability

Uncertain based on 1 antibody.
HPA067683
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Mixed

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

ATG4D (HGNC Symbol)

Synonyms

APG4-D, APG4D, AUTL4

Description

Autophagy related 4D, cysteine peptidase (HGNC Symbol)

Entrez gene summary

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

19

Cytoband

p13.2

Chromosome location (bp)

10543895 - 10553418

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000130734 (version 78.38)

Entrez gene

84971

UniProt

Q86TL0 (UniProt - Evidence at protein level)

neXtProt

NX_Q86TL0

Antibodypedia

ATG4D antibodies


PROTEIN BROWSER

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ENST00000309469
 
ENST00000585437
 
ENST00000586477
 
ENST00000586863
 
ENST00000587256
 
ENST00000588972
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATG4D-001 ENSP00000311318
ENST00000309469
Q86TL0
Show all »
Show » Show » 474 52.9 No 0
ATG4D-007 ENSP00000467223
ENST00000586477
K7EP43
Show all »
Show » Show » 209 23.3 No 0
ATG4D-008 ENSP00000465089
ENST00000586863
Show » 177 19.9 No 0
ATG4D-009 ENSP00000468780
ENST00000587256
Show » 203 22.7 No 0
ATG4D-010 ENSP00000466759
ENST00000588972
K7EN30
Show all »
Show » Show » 177 19.7 No 0
ATG4D-011 ENSP00000467694
ENST00000585437
K7EQ67
Show all »
Show » Show » 99 11.3 No 0