RLIM

GENERAL INFORMATION

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Gene name

RLIM

Gene description

Ring finger protein, LIM domain interacting

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Most of the normal tissues displayed moderate cytoplasmic and/or nuclear positivity. Strong cytoplasmic staining was seen in gastro-intestinal tract, smooth and skeletal muscles while respiratory and squamous epithelia and endocrine glands showed strong nuclear staining. Hepatocytes and alveolar cells were negative.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA018895
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

RLIM (HGNC Symbol)

Synonyms

MGC15161, NY-REN-43, RNF12

Description

Ring finger protein, LIM domain interacting (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]

Chromosome

X

Cytoband

q13.2

Chromosome location (bp)

74585217 - 74614617

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000131263 (version 78.38)

Entrez gene

51132

UniProt

Q9NVW2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NVW2

Antibodypedia

RLIM antibodies


PROTEIN BROWSER

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ENST00000332687
 
ENST00000349225
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RLIM-001 ENSP00000328059
ENST00000332687
Q9NVW2
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Show » Show » 624 68.5 No 0
RLIM-002 ENSP00000253571
ENST00000349225
Q9NVW2
Show all »
Show » Show » 624 68.5 No 0