The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Most normal tissues displayed weak o moderate membranous and/or cytoplasmic positivity. Duodenum displayed strong positivity. Strong membranous staining was observed in renal tubules. Endothelial cells were distinctly stained. Hepatocytes, hippocampus, lymphoid cells, myocytes and adipocytes were negative.
Gastrointestinal tract and fallopian tube showed moderate cytoplasmic staining. Colon and stomach displayed additional nuclear staining while rectum exhibited additional luminal membranous positivity. Purkinje cells, glial cells, salivary gland and uterine gland showed moderate cytoplasmic and nuclear positivity while appendix displayed strong immunoreactivity. Remaining normal tissues were weakly stained or negative.
Most normal tissues displayed moderate to strong cytoplasmic positivity. Alveolar cells type II showed strong immunoreactivity. Squamous epithelia and lymphoid tissues were weakly stained or negative.