MKRN1

GENERAL INFORMATION

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Gene name

MKRN1

Gene description

Makorin ring finger protein 1

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

9
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HUMAN PROTEIN ATLAS INFORMATION

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RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all

Protein evidence

Evidence at protein level

Protein localization

Normal cells showed weak to moderate cytoplasmic positivity.

ANTIBODY RELIABILITY

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Data reliability
description

Pending RNA-based expert annotation.

Data reliability

Uncertain based on 1 antibody.
HPA000567
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RNA AND PROTEIN EXPRESSION SUMMARY

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RNA expression (FPKM) Protein expression (score)
Brain
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis



PROTEIN EXPRESSION OVERVIEW

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Organ

Expression



RNA EXPRESSION OVERVIEW

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HPA dataset
RNA tissue category:  Expressed in all

Organ

Expression

GTEx dataset
RNA tissue category:  Expressed in all

Organ

Expression



GENE INFORMATION

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Gene name

MKRN1 (HGNC Symbol)

Synonyms

RNF61

Description

Makorin ring finger protein 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the telomerase ribonucleoprotein. This protein controls cell cycle arrest and apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

Chromosome

7

Cytoband

q34

Chromosome location (bp)

140453040 - 140479569

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000133606 (version 78.38)

Entrez gene

23608

UniProt

Q9UHC7 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UHC7

Antibodypedia

MKRN1 antibodies


PROTEIN BROWSER

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ENST00000255977
 
ENST00000443720
 
ENST00000463142
 
ENST00000467513
 
ENST00000471104
 
ENST00000473444
 
ENST00000474576
 
ENST00000480552
 
ENST00000494939
 
 
 
 


PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MKRN1-001 ENSP00000255977
ENST00000255977
Q9UHC7
Show all »
Show » Show » 482 53.3 No 0
MKRN1-002 ENSP00000416369
ENST00000443720
Q9UHC7
Show all »
Show » Show » 329 35.2 No 0
MKRN1-007 ENSP00000417863
ENST00000474576
Q9UHC7
Show all »
Show » Show » 418 47.6 No 0
MKRN1-011 ENSP00000418864
ENST00000471104
C9IY57
Show all »
Show » Show » 193 21.1 No 0
MKRN1-012 ENSP00000418620
ENST00000473444
C9IZP5
Show all »
Show » Show » 102 11.3 No 0
MKRN1-013 ENSP00000418588
ENST00000467513
C9J031
Show all »
Show » Show » 165 18 No 0
MKRN1-014 ENSP00000419843
ENST00000494939
C9JYX8
Show all »
Show » Show » 136 14.7 No 0
MKRN1-015 ENSP00000419894
ENST00000480552
C9JYI0
Show all »
Show » Show » 111 12.2 No 0
MKRN1-018 ENSP00000417346
ENST00000463142
H7C4H5
Show all »
Show » 112 12.6 No 0