CTSL protein expression summary - The Human Protein Atlas

HUMAN PROTEIN ATLAS SUMMARYⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Proteinⁱ Full gene name according to HGNC.	Cathepsin L
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CTSL (CTSL1, FLJ31037)
Tissue specificityⁱ ??The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Tissue enhanced (placenta)
Tissue expression clusterⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Liver - Lipid metabolism (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts, Hofbauer cells, Cytotrophoblasts, Extravillous trophoblasts, Hepatic stellate cells, Macrophages)
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Innate immune response (mainly)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed blood cell samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (non-classical monocyte, intermediate monocyte)
Brain specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category Read more	Low human brain regional specificity
Cancer prognostic summary	Prognostic marker in lung cancer (unfavorable), glioma (unfavorable) and renal cancer (favorable)
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Subcellular summaryⁱ Describes the main and potential additional location(s) of the encoded protein according to ICC-IF resukt in the Cell Atlas, as well as potential data regarding cell cycle depency (CCD) for the RNA and/or protein expression.	Located in Golgi apparatus, Vesicles
Protein function (UniProt)ⁱ Useful information about the protein provided by UniProt.	Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Plays a critical for normal cellular functions such as general protein turnover, antigen processing and bone remodeling. Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (By similarity). In neuroendocrine chromaffin cells secretory vesicles, catalyzes the prohormone proenkephalin processing to the active enkephalin peptide neurotransmitter (By similarity). In thymus, regulates CD4(+) T cell positive selection by generating the major histocompatibility complex class II (MHCII) bound peptide ligands presented by cortical thymic epithelial cells. Also mediates invariant chain processing in cortical thymic epithelial cells (By similarity). Major elastin-degrading enzyme at neutral pH. Accumulates as a mature and active enzyme in the extracellular space of antigen presenting cells (APCs) to regulate degradation of the extracellular matrix in the course of inflammation (By similarity). Secreted form generates endostatin from COL18A1 1. Critical for cardiac morphology and function. Plays an important role in hair follicle morphogenesis and cycling, as well as epidermal differentiation (By similarity). Required for maximal stimulation of steroidogenesis by TIMP1 (By similarity).... show less
Molecular function (UniProt)ⁱ Keywords assigned by UniProt to proteins due to their particular molecular function.	Hydrolase, Protease, Thiol protease
Disease involvementⁱ Disease related keywords assigned by UniProt combined with Cancer-related genes and FDA approved drug targets Read more	Cancer-related genes
Gene summary (Entrez)ⁱ Useful information about the gene from Entrez	The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell. [provided by RefSeq, Aug 2020]... show less

TISSUEⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more

Tissue expression clusterⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Liver - Lipid metabolism (mainly)
Tissue specificityⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Tissue enhanced (placenta)
Tissue distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Protein expressionⁱ A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation. "Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile. Read more	Lysosomal expression in several tissues.

BRAINⁱ Summary of data presented in the Brain Atlas and a representative image of mRNA expression in the human brain. The image is clickable and will redirect to more Brain Atlas data. The Brain Atlas explores the protein expression in the mammalian brain by visualization and integration of data from three mammalian species (human, pig and mouse). Transcriptomics data combined with affinity-based protein in situ localization down to single cell level is available in a brain-centric sub atlas of the Human Protein Atlas. Read more

Human regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Pig regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity

SINGLE CELL TYPEⁱ Summary of data presented in the Single cell Type section, with an interactive chart showing the cell type-specific mRNA expression. The chart is clickable and will redirect to more Cell Type data. This section contains information about single cell type RNA expression based on scRNAseq of human tissues. The data also covers transcriptomics analysis of human blood and cultured cell lines. Read more

Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Innate immune response (mainly)
Cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts, Hofbauer cells, Cytotrophoblasts, Extravillous trophoblasts, Hepatic stellate cells, Macrophages)

TISSUE CELL TYPEⁱ

Spermatocytes

Classificationⁱ

Cell type enriched in single tissue

PATHOLOGYⁱ Summary of data presented in the Pathology section, with representative images of protein expression in cancer (left) and correlation between mRNA expression and patient survival (right). Images are clickable and redirect to pages with more Pathology data. This section contains mRNA and protein expression data from 17 different forms of human cancer, as well as correlation analysis of mRNA expression and patient survival. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more
	Lung cancer p<0.001
Prognostic summary	Prognostic marker in lung cancer (unfavorable), glioma (unfavorable) and renal cancer (favorable)
Cancer specificityⁱ Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. Read more	Low cancer specificity
Cancer distributionⁱ Distribution of RNA expression in 17 cancer types is categorized as either detected in single, detected in some, detected in many, detected in all, or not detected. Read more	Detected in all

IMMUNE CELLⁱ Summary of data presented in the Immune Cell section and a representative image of mRNA expression in immune cells in the blood. The image is clickable and will redirect to more immune cell related data. The Immune Cell section contains information regarding single cell type mRNA expression profiles of protein-coding genes in various immune cells in the blood, e.g. B-cells and granulocytes. Read more

Immune cell expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Monocytes - Innate immune response (mainly)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (non-classical monocyte, intermediate monocyte)

BLOOD PROTEINⁱ Summary of data presented in the Blood proteins section and a representative image of the concentration in plasma and related function for the protein in plasma. The image is clickable and will redirect to more data. The Blood proteins section contains plasma levels of proteins detected in human blood and an analysis of the human secretome (including annotation of the genes predicted to be actively secreted to human blood) is also presented. Read more
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes. Read more	Intracellular and membrane
Detected in blood by immunoassayⁱ The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search. Read more	No (not applicable)
Detected in blood by mass spectrometryⁱ Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics data set obtained from the PeptideAtlas.	Yes
Detected in blood by proximity extension assayⁱ Detection or not of the gene in blood, based on proximity extension assays (Olink) for a longitudinal wellness study covering 76 individuals with three visits during two years. Read more	Yes

SUBCELLULARⁱ Summary of data presented in the Cell Atlas and a representative image of subcellular localization. The Cell Atlas provides RNA expression data derived from RNA sequencing of a large panel of cell lines and protein localization data derived from antibody-based profiling by immunofluorescence confocal microscopy, using a subset of cell lines selected based on RNA expression. Read more

Main locationⁱ Main subcellular location(s) and reliability score(s) for the encoded protein(s) in human cells. The main location(s) may be characterized by presence in all tested cell lines and/or ihigher staining intensity compared to the potential additional location(s). If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively. Read more	Localized to the Golgi apparatus, Vesicles

CELL LINEⁱ Summary of data presented in the Cell Line section and a representative image of mRNA expression across different human cell lines. The image is clickable and will redirect to more cell line data. This section contains information regarding mRNA expression profiles of human protein-coding genes for a large variety of cell lines. Read more

Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Mesenchymal cell lines - ECM organization (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (ASC TERT1, HSkMC)
Cell type distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many

METABOLIC

Metabolic info	Present in 1 pathway

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	CTSL (HGNC Symbol)
Synonyms	CTSL1, FLJ31037
Description	Cathepsin L (HGNC Symbol)
Chromosome	9
Cytoband	q21.33
Chromosome location (bp)	87724051 - 87731469
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	20
Protein evidence	Evidence at protein level (all genes)
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes Metabolic proteins Plasma proteins
Ensembl	ENSG00000135047 (version 103.38)
Entrez gene	1514
UniProt	P07711 (UniProt - Evidence at protein level)
neXtProt	NX_P07711
Antibodypedia	CTSL antibodies

PROTEIN BROWSERⁱ

CTSL-201

CTSL-202

CTSL-203

CTSL-208

CTSL-209

CTSL-211

CTSL-212

CTSL-214

CTSL-216

CTSL-217

CTSL-223

CTSL-224

CTSL-225

CTSL-230

CTSL-231

CTSL-232

CTSL-233

CTSL-239

CTSL-241

CTSL-242

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CTSL-201 ENSP00000365061 ENST00000340342	P07711 [Direct mapping] Cathepsin L1 Cathepsin L1 heavy chain Cathepsin L1 light chain A0A024R276 [Target identity:100%; Query identity:100%] Cathepsin L, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Metabolic proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) Show all	GO:0001968 [fibronectin binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005764 [lysosome] GO:0005771 [multivesicular body] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0006955 [immune response] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0016540 [protein autoprocessing] GO:0016787 [hydrolase activity] GO:0019064 [fusion of virus membrane with host plasma membrane] GO:0019065 [receptor-mediated endocytosis of virus by host cell] GO:0019882 [antigen processing and presentation] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0022617 [extracellular matrix disassembly] GO:0030574 [collagen catabolic process] GO:0031410 [cytoplasmic vesicle] GO:0031638 [zymogen activation] GO:0034230 [enkephalin processing] GO:0036021 [endolysosome lumen] GO:0039654 [fusion of virus membrane with host endosome membrane] GO:0042393 [histone binding] GO:0042583 [chromaffin granule] GO:0043202 [lysosomal lumen] GO:0043231 [intracellular membrane-bounded organelle] GO:0043373 [CD4-positive, alpha-beta T cell lineage commitment] GO:0043394 [proteoglycan binding] GO:0045616 [regulation of keratinocyte differentiation] GO:0046718 [viral entry into host cell] GO:0048002 [antigen processing and presentation of peptide antigen] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0060309 [elastin catabolic process] GO:0062023 [collagen-containing extracellular matrix] GO:0070062 [extracellular exosome] GO:0071888 [macrophage apoptotic process] GO:0097067 [cellular response to thyroid hormone stimulus] GO:0097655 [serpin family protein binding] Show all	333 aa 37.6 kDa	Yes	0
CTSL-202 ENSP00000340470 ENST00000342020	Q5T8F0 [Direct mapping] Cathepsin L1 Show all	Metabolic proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005764 [lysosome] GO:0005794 [Golgi apparatus] GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] GO:0043231 [intracellular membrane-bounded organelle] Show all	272 aa 30.6 kDa	Yes	0
CTSL-203 ENSP00000345344 ENST00000343150	P07711 [Direct mapping] Cathepsin L1 Cathepsin L1 heavy chain Cathepsin L1 light chain A0A024R276 [Target identity:100%; Query identity:100%] Cathepsin L, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Metabolic proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001968 [fibronectin binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005764 [lysosome] GO:0005771 [multivesicular body] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0006955 [immune response] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0016540 [protein autoprocessing] GO:0016787 [hydrolase activity] GO:0019064 [fusion of virus membrane with host plasma membrane] GO:0019065 [receptor-mediated endocytosis of virus by host cell] GO:0019882 [antigen processing and presentation] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0022617 [extracellular matrix disassembly] GO:0030574 [collagen catabolic process] GO:0031410 [cytoplasmic vesicle] GO:0031638 [zymogen activation] GO:0034230 [enkephalin processing] GO:0036021 [endolysosome lumen] GO:0039654 [fusion of virus membrane with host endosome membrane] GO:0042393 [histone binding] GO:0042583 [chromaffin granule] GO:0043202 [lysosomal lumen] GO:0043231 [intracellular membrane-bounded organelle] GO:0043373 [CD4-positive, alpha-beta T cell lineage commitment] GO:0043394 [proteoglycan binding] GO:0045616 [regulation of keratinocyte differentiation] GO:0046718 [viral entry into host cell] GO:0048002 [antigen processing and presentation of peptide antigen] GO:0051603 [proteolysis involved in cellular protein catabolic process] GO:0060309 [elastin catabolic process] GO:0062023 [collagen-containing extracellular matrix] GO:0070062 [extracellular exosome] GO:0071888 [macrophage apoptotic process] GO:0097067 [cellular response to thyroid hormone stimulus] GO:0097655 [serpin family protein binding] Show all	333 aa 37.6 kDa	Yes	0
CTSL-208 ENSP00000504279 ENST00000676480	A0A024R276 [Target identity:100%; Query identity:100%] Cathepsin L, isoform CRA_a Show all	Metabolic proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005764 [lysosome] GO:0005794 [Golgi apparatus] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0016787 [hydrolase activity] GO:0043231 [intracellular membrane-bounded organelle] Show all	333 aa 37.6 kDa	Yes	0
CTSL-209 ENSP00000503439 ENST00000676531	A0A024R276 [Target identity:100%; Query identity:100%] Cathepsin L, isoform CRA_a Show all	Metabolic proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005764 [lysosome] GO:0005794 [Golgi apparatus] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0016787 [hydrolase activity] GO:0043231 [intracellular membrane-bounded organelle] Show all	333 aa 37.6 kDa	Yes	0
CTSL-211 ENSP00000504405 ENST00000676769		Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] Show all	278 aa 31.2 kDa	No	0
CTSL-212 ENSP00000502901 ENST00000676881	A0A024R276 [Target identity:100%; Query identity:100%] Cathepsin L, isoform CRA_a Show all	Metabolic proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005764 [lysosome] GO:0005794 [Golgi apparatus] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0016787 [hydrolase activity] GO:0043231 [intracellular membrane-bounded organelle] Show all	333 aa 37.6 kDa	Yes	0
CTSL-214 ENSP00000503470 ENST00000676946	A0A024R276 [Target identity:100%; Query identity:100%] Cathepsin L, isoform CRA_a Show all	Metabolic proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005764 [lysosome] GO:0005794 [Golgi apparatus] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0016787 [hydrolase activity] GO:0043231 [intracellular membrane-bounded organelle] Show all	333 aa 37.6 kDa	Yes	0
CTSL-216 ENSP00000504473 ENST00000677019		Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] Show all	278 aa 31.2 kDa	No	0
CTSL-217 ENSP00000503851 ENST00000677262	A0A024R276 [Target identity:100%; Query identity:100%] Cathepsin L, isoform CRA_a Show all	Metabolic proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005764 [lysosome] GO:0005794 [Golgi apparatus] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0016787 [hydrolase activity] GO:0043231 [intracellular membrane-bounded organelle] Show all	333 aa 37.6 kDa	Yes	0
CTSL-223 ENSP00000503938 ENST00000677761	A0A024R276 [Target identity:100%; Query identity:100%] Cathepsin L, isoform CRA_a Show all	Metabolic proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005764 [lysosome] GO:0005794 [Golgi apparatus] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0016787 [hydrolase activity] GO:0043231 [intracellular membrane-bounded organelle] Show all	333 aa 37.6 kDa	Yes	0
CTSL-224 ENSP00000503298 ENST00000677821	A0A024R276 [Target identity:100%; Query identity:100%] Cathepsin L, isoform CRA_a Show all	Metabolic proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005764 [lysosome] GO:0005794 [Golgi apparatus] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0016787 [hydrolase activity] GO:0043231 [intracellular membrane-bounded organelle] Show all	333 aa 37.6 kDa	Yes	0
CTSL-225 ENSP00000503881 ENST00000677864		Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] Show all	278 aa 31.2 kDa	No	0
CTSL-230 ENSP00000503897 ENST00000678442	A0A024R276 [Target identity:100%; Query identity:100%] Cathepsin L, isoform CRA_a Show all	Metabolic proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005764 [lysosome] GO:0005794 [Golgi apparatus] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0016787 [hydrolase activity] GO:0043231 [intracellular membrane-bounded organelle] Show all	333 aa 37.6 kDa	Yes	0
CTSL-231 ENSP00000503146 ENST00000678596		Metabolic proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] Show all	341 aa 38.8 kDa	Yes	0
CTSL-232 ENSP00000504676 ENST00000678599		Metabolic proteins MEMSAT3 predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] Show all	258 aa 29.6 kDa	Yes	0
CTSL-233 ENSP00000504772 ENST00000678649		Metabolic proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] Show all	341 aa 38.8 kDa	Yes	0
CTSL-239 ENSP00000503891 ENST00000679030		Metabolic proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008234 [cysteine-type peptidase activity] Show all	209 aa 23.7 kDa	Yes	0
CTSL-241 ENSP00000504313 ENST00000679149	A0A024R276 [Target identity:100%; Query identity:100%] Cathepsin L, isoform CRA_a Show all	Metabolic proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005764 [lysosome] GO:0005794 [Golgi apparatus] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0016787 [hydrolase activity] GO:0043231 [intracellular membrane-bounded organelle] Show all	333 aa 37.6 kDa	Yes	0
CTSL-242 ENSP00000502968 ENST00000679157	A0A024R276 [Target identity:100%; Query identity:100%] Cathepsin L, isoform CRA_a Show all	Metabolic proteins MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005764 [lysosome] GO:0005794 [Golgi apparatus] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0016787 [hydrolase activity] GO:0043231 [intracellular membrane-bounded organelle] Show all	333 aa 37.6 kDa	Yes	0